About: Antibody-Dependent Cellular Phagocytosis of HIV-1-Infected Cells Is Efficiently Triggered by IgA Targeting HIV-1 Envelope Subunit gp41

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About: Antibody-Dependent Cellular Phagocytosis of HIV-1-Infected Cells Is Efficiently Triggered by IgA Targeting HIV-1 Envelope Subunit gp41 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antibody-Dependent Cellular Phagocytosis of HIV-1-Infected Cells Is Efficiently Triggered by IgA Targeting HIV-1 Envelope Subunit gp41
Creator	Bomsel, Morgane Tomaras, Georgia Cottignies-Calamarte, Andréa Duchemin, Maxence Tudor, Daniela Bland, Paul Ferrari, Guido
Source	Medline; PMC
abstract	Antibodies mediate a broad array of non-neutralizing Fc-mediated functions against HIV-1 including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Accordingly, ADCC and ADCP induced by anti-HIV envelope gp120 IgG have been correlated to the limited success of the HIV-1 phase III vaccine trial RV144. It remains elusive whether ADCP can also be triggered by IgA, the isotype predominant at mucosal surfaces through which HIV-1 is mainly transmitted. Yet, we have previously shown that the HIV envelope subunit gp41-specific broadly neutralizing antibody 2F5 under the IgA isotype (2F5-IgA) triggers ADCC and cooperates with 2F5-IgG to increase HIV-1-infected cell lysis. Here, we now demonstrate that 2F5-IgA, more efficiently than 2F5-IgG, induces ADCP not only of gp41-coated beads but also of primary HIV-1-infected cells in a FcαRI-dependent manner. Both primary monocytes and neutrophils can act as effector cells of 2F5-IgA-mediated ADCP, although with different kinetics with faster neutrophil phagocytosis. However, unlike for ADCC, 2F5-IgA and 2F5-IgG do not cooperate to increase ADCP. Altogether, our results reveal that gp41-specific IgA mediate the efficient phagocytosis of HIV-1-infected cells. Inducing such ADCC and ADCP-prone IgA response by vaccination in addition to anti-HIV envelope IgG, might increase the protection against HIV acquisition at mucosal level.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.01141
bibo:pmid	32582208
has license	cc-by
sha1sum (hex)	c49a80e0dc066e776c173924fa645f52b0cb90b6
schema:url	https://doi.org/10.3389/fimmu.2020.01141
resource representing a document's title	Antibody-Dependent Cellular Phagocytosis of HIV-1-Infected Cells Is Efficiently Triggered by IgA Targeting HIV-1 Envelope Subunit gp41
has PubMed Central identifier	PMC7296124
has PubMed identifier	32582208
schema:publication	Front Immunol
resource representing a document's body	covid:c49a80e0dc066e776c173924fa645f52b0cb90b6#body_text
is schema:about of	named entity 'HIV-1' named entity 'subunit' named entity 'ADCC' named entity 'vaccination' named entity 'IgA' named entity 'neutralizing antibody' named entity 'ADCC' named entity 'HIV envelope' covid:arg/c49a80e0dc066e776c173924fa645f52b0cb90b6 named entity 'HIV-1' named entity 'IgG' named entity 'phagocytosis' named entity 'elusive' named entity 'phagocytosis' named entity 'isotype' named entity 'reveal' named entity 'HIV-1' named entity 'phase III' named entity 'Envelope' named entity 'effector cells' named entity 'IgG' named entity 'HIV envelope' named entity 'RV144' named entity 'ADCP' named entity 'HIV-1' named entity 'phagocytosis' named entity 'monocytes' named entity 'IgG' named entity 'phase III' named entity 'IgA' named entity 'ADCP' named entity 'HIV-1' named entity 'vaccine' named entity 'gp120' named entity 'antibody-dependent cellular cytotoxicity' named entity 'vaccination' named entity 'gp41' named entity 'IgA' named entity 'HIV-1' named entity 'Subunit' named entity 'Antibody' named entity 'efficient' named entity 'ADCP' named entity 'glycosylation' named entity 'monocytes' named entity 'intracellular' named entity 'CD4 +' named entity 'HIV' named entity 'efficacies' named entity 'mannose' named entity 'antibody' named entity 'statistically significant' named entity 'HIV' named entity 'HIV-1' named entity 'lymphocytes' named entity 'anti-HIV' named entity 'IgA' named entity 'Brea' named entity 'opsonized' named entity 'lymphocytes' named entity 'HIV-1' named entity 'IgG' named entity 'ADCP' named entity 'fluorescence' named entity 'phagocytosis' named entity 'opsonized' named entity 'CD89' named entity 'vaccine' named entity 'Germany' named entity 'gp120' named entity 'IgG' named entity 'cytokine' named entity 'IgG' named entity 'HIV-1' named entity 'ADCP'

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