About: Pepitope: epitope mapping from affinity-selected peptides

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About: Pepitope: epitope mapping from affinity-selected peptides Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pepitope: epitope mapping from affinity-selected peptides
Creator	Gershoni, Jonathan Freund, Natalia Bublil, Erez Erez, Elana Martz, Eric Mayrose, Itay Penn, Osnat Pupko, Tal Rubinstein, Nimrod Ruppin, Eytan Sharan, Roded Shlomi, Tomer
Source	PMC
abstract	Identifying the epitope to which an antibody binds is central for many immunological applications such as drug design and vaccine development. The Pepitope server is a web-based tool that aims at predicting discontinuous epitopes based on a set of peptides that were affinity-selected against a monoclonal antibody of interest. The server implements three different algorithms for epitope mapping: PepSurf, Mapitope, and a combination of the two. The rationale behind these algorithms is that the set of peptides mimics the genuine epitope in terms of physicochemical properties and spatial organization. When the three-dimensional (3D) structure of the antigen is known, the information in these peptides can be used to computationally infer the corresponding epitope. A user-friendly web interface and a graphical tool that allows viewing the predicted epitopes were developed. Pepitope can also be applied for inferring other types of protein–protein interactions beyond the immunological context, and as a general tool for aligning linear sequences to a 3D structure. Availability: http://pepitope.tau.ac.il/ Contact: talp@post.tau.ac.il
has issue date	2007-12-01(xsd:dateTime)
bibo:doi	10.1093/bioinformatics/btm493
bibo:pmid	17977889
has license	no-cc
sha1sum (hex)	c43534bdac307a5c7c6b9d8ddf1f852aa355a3b2
schema:url	https://doi.org/10.1093/bioinformatics/btm493
resource representing a document's title	Pepitope: epitope mapping from affinity-selected peptides
has PubMed Central identifier	PMC7110138
has PubMed identifier	17977889
schema:publication	Bioinformatics
resource representing a document's body	covid:c43534bdac307a5c7c6b9d8ddf1f852aa355a3b2#body_text
is schema:about of	named entity 'AFFINITY' named entity 'epitope' named entity 'server' named entity 'The' named entity 'aims' named entity 'protein-protein interactions' named entity 'PEPTIDES' named entity 'PEPTIDES' named entity 'IMMUNOLOGICAL' named entity 'SPATIAL ORGANIZATION' named entity 'OF INTEREST' named entity 'BINDS' named entity 'LINEAR' named entity 'INTERFACE' named entity 'APPLIED' named entity 'DISCONTINUOUS' named entity 'PREDICTING' named entity 'ALLOWS' named entity 'CONTEXT' named entity 'SELECTED' named entity 'EPITOPE MAPPING' named entity 'SEQUENCES' named entity 'MONOCLONAL ANTIBODY' named entity 'AIMS' named entity 'USED' named entity 'VIEWING' named entity 'THESE' named entity 'VACCINE DEVELOPMENT' named entity 'TERMS' named entity 'INFER' named entity 'INFORMATION' named entity 'ANTIBODY' named entity 'APPLICATIONS' named entity 'ANTIGEN' named entity 'IS A' named entity 'IDENTIFYING' named entity 'CENTRAL' named entity 'EPITOPE' named entity 'PROTEIN-PROTEIN INTERACTIONS' named entity 'THREE-DIMENSIONAL' named entity 'WEB' named entity 'EPITOPES' named entity 'KNOWN' named entity 'ALGORITHMS' named entity 'MIMICS' named entity 'TOOL' named entity 'DRUG DESIGN' named entity 'BEYOND' named entity 'BASED' named entity 'EPITOPE MAPPING' named entity 'INFERRING' named entity 'SET' named entity 'COMBINATION' named entity 'STRUCTURE' named entity 'DIFFERENT' named entity 'SELECTED' named entity 'PREDICTED' named entity 'ALIGNING' named entity 'SERVER' named entity 'GENERAL' named entity 'TYPES' named entity 'PHYSICOCHEMICAL PROPERTIES' named entity 'AFFINITY' named entity 'RATIONALE' named entity 'immunological' named entity 'binds' named entity 'set' named entity 'drug design' named entity 'computational methods' named entity 'gap penalty'

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