About: Molecular epidemiology and genetic variation analyses of porcine circovirus type 2 isolated from Yunnan Province in China from 2016-2019

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About: Molecular epidemiology and genetic variation analyses of porcine circovirus type 2 isolated from Yunnan Province in China from 2016-2019 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular epidemiology and genetic variation analyses of porcine circovirus type 2 isolated from Yunnan Province in China from 2016-2019
Creator	Wang, Yuan Zhu, Li Liu, Lu Chai, Jun Hong, Jinmei Li, Wengui Li, Zhilan Lv, Nianci Qian, Qisheng Zhang, Tianyu Zhang, Yifang Zheng, Xiaolin
topic	covid:c42f33171b8532b51242b08230d57f4e8bdc041f#this
Source	PMC
abstract	BACKGROUND: Porcine circovirus type 2 (PCV2) is the causative agent of porcine circovirus-associated disease (PCVAD). Its prevalence in swine herds was first reported in China in 2000. PCV2 infection causes immunosuppression that leads to multiple diseases, causing serious economic problems for the swine industry in China. Since information on the genetic variation of PCV2 in Yunnan province is limited, this study aims to investigate the molecular epidemiological and evolutionary characteristics of PCV2 from 2016 to 2019. METHODS: A total of 279 clinical samples were collected from different regions of Yunnan between 2016 to 2019, and PCV2 was detected by PCR. We then amplified full genomes from the positive samples, and the sequences were analysed for homology and genetic evolution. RESULTS: Overall, 60.93% (170/279) of the screened swine herd samples were positive for PCV2. We sequenced 15 Yunnan province PCV2 strains from positive samples. Analyses of the complete genomes and Cap genes led to the classification of the 15 Yunnan PCV2 strains into PCV2a (2 of 15), PCV2b (1of 15) and PCV2d (12 of 15). All strains shared 94.3–99.9% of their identities with the nucleotide sequences of complete genomes in this study and shared 94.2–99.9% identity with the reference sequences. All strains share 89.4–100% and 86.8–100% of their identities with the nucleotide and amino acid (aa) sequences of Cap, respectively. CONCLUSIONS: The results of this study provide evidence that PCV2a, PCV2b and PCV2d genotypes coexisted in Yunnan Province from 2016 to 2019, and the priority prevalence genotype was PCV2d. The data provide evidence for the increased genetic diversity and insights into the molecular epidemiology of PCV2. This study also provides basic data for the Yunnan province PCV2 molecular epidemiological survey and accumulates effective materials for the development of PCV2 vaccines.
has issue date	2020-03-23(xsd:dateTime)
bibo:doi	10.1186/s12917-020-02304-8
bibo:pmid	32293447
has license	cc-by
sha1sum (hex)	c42f33171b8532b51242b08230d57f4e8bdc041f
schema:url	https://doi.org/10.1186/s12917-020-02304-8
resource representing a document's title	Molecular epidemiology and genetic variation analyses of porcine circovirus type 2 isolated from Yunnan Province in China from 2016-2019
has PubMed Central identifier	PMC7087357
has PubMed identifier	32293447
schema:publication	BMC Vet Res
resource representing a document's body	covid:c42f33171b8532b51242b08230d57f4e8bdc041f#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/c42f33171b8532b51242b08230d57f4e8bdc041f
is schema:about of	named entity '2016' named entity 'leads' named entity 'nucleotide' named entity 'genotypes' named entity 'complete' named entity 'sequenced' named entity 'strains' named entity 'China' named entity 'insights' named entity 'EVIDENCE FOR' named entity 'GENETIC VARIATION' named entity 'LEADS' named entity 'Yunnan' named entity 'Cap' named entity '2016' named entity 'epidemiological' named entity 'sequences' named entity 'Yunnan' named entity 'Yunnan' named entity 'competent cells' named entity 'homology' named entity 'vaccination' named entity 'sequence analysis' named entity 'genetic diversity' named entity 'genotype' named entity '99.9%' named entity 'serum samples' named entity 'pig' named entity 'sequence analysis' named entity 'vaccine' named entity 'genetic diversity' named entity 'ORF2' named entity 'clades' named entity 'phylogenetic analyses' named entity 'ORF1' named entity 'infection' named entity 'virus' named entity 'PCVAD' named entity 'PCV2' named entity 'PCV1' named entity 'PCV2' named entity 'epidemiology' named entity 'recombinants' named entity 'genotype' named entity 'PCV2' named entity 'PCV2' named entity 'ORFs' named entity 'ORFs' named entity 'porcine' named entity 'primers' named entity 'evolutionary dynamics' named entity 'Yunnan' named entity 'genotype' named entity 'genotype' named entity 'virus' named entity 'Yunnan' named entity 'PCV2' named entity 'PCV2' named entity 'epidemiological data' named entity 'PCV2' named entity 'Yunnan' named entity 'antibody' named entity 'PCV2' named entity '94.3' named entity 'vaccine strain' named entity 'PCV2' named entity 'antigens' named entity 'nucleotides'

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