About: Identification of a novel linear B-cell epitope in nonstructural protein 11 of porcine reproductive and respiratory syndrome virus that are conserved in both genotypes

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About: Identification of a novel linear B-cell epitope in nonstructural protein 11 of porcine reproductive and respiratory syndrome virus that are conserved in both genotypes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of a novel linear B-cell epitope in nonstructural protein 11 of porcine reproductive and respiratory syndrome virus that are conserved in both genotypes
Creator	Jiang, Nan Zhou, Lei Ge, Xinna Guo, Xin Yang, Hanchun Han, Jun Jin, Li,
Source	Medline; PMC
abstract	Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogens, that hinder the development of global pork industry. Its nonstructural protein 11 (nsp11), with the nidoviral uridylate-specific endoribonuclease (NendoU) domain, is essential for PRRSV genome replication and it also contributes to host innate immunity suppression. However, the immunogenicity and immune structure of PRRSV nsp11 have not been well investigated yet. In this study, a monoclonal antibody (mAb), designated 3F9, that against nsp11 was generated. Subsequently, a series of partially overlapped fragments, covered the nsp11(40-223aa), were expressed to test the reactivity with mAb 3F9, and the (111)DCREY(115) was found to be the core unit of the B-cell epitope recognized by mAb 3F9. Further investigation indicated that both genotype 1 and genotype 2 PRRSV can be recognized by mAb 3F9, due to the (111)DCREY(115) is conserved in both genotype virus. Meanwhile, this epitope, localized at the surface of nsp11 in 3D structure, is confirmed to be able to induce humoral immune response in PRRSV infected pigs. These findings do not only provide an mAb tool to further investigate the function of nsp11, they also indicate the diagnostic potential for this epitope.
has issue date	2017-11-29(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0188946
bibo:pmid	29186182
has license	cc-by
sha1sum (hex)	c417b7235950a6e64054e00d24f75e2e5c748349
schema:url	https://doi.org/10.1371/journal.pone.0188946
resource representing a document's title	Identification of a novel linear B-cell epitope in nonstructural protein 11 of porcine reproductive and respiratory syndrome virus that are conserved in both genotypes
has PubMed Central identifier	PMC5706702
has PubMed identifier	29186182
schema:publication	PLoS One
resource representing a document's body	covid:c417b7235950a6e64054e00d24f75e2e5c748349#body_text
is schema:about of	named entity 'PROTEIN ' named entity 'PARTIALLY' named entity 'URIDYLATE-SPECIFIC ENDORIBONUCLEASE' named entity 'OVERLAPPED' named entity 'CONSERVED' named entity 'PIGS' named entity 'DEVELOPMENT' named entity 'IDENTIFICATION' named entity 'SERIES' named entity 'REPLICATION' named entity 'MONOCLONAL ANTIBODY' named entity 'CONFIRMED' named entity 'INDUCE' named entity 'SUPPRESSION' named entity 'ITS' named entity 'INDUSTRY' named entity 'PATHOGENS' named entity 'FUNCTION' named entity 'FINDINGS' named entity 'GLOBAL' named entity 'INVESTIGATE' named entity 'DUE TO' named entity 'THESE' named entity 'DIAGNOSTIC' named entity 'COVERED' named entity 'EPITOPE' named entity 'GENERATED' named entity 'LINEAR' named entity 'IDENTIFICATION' named entity 'NOVEL' named entity 'B-CELL EPITOPE' named entity 'GENOTYPE' named entity 'STRUCTURE' named entity 'SURFACE' named entity 'IMMUNE' named entity 'INVESTIGATION INDICATED' named entity 'REACTIVITY' named entity 'PORK' named entity '111' named entity 'ECONOMICALLY IMPORTANT' named entity 'ORG' named entity 'CORE' named entity 'IMMUNOGENICITY' named entity 'PROVIDE' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'DO NOT' named entity 'GENOTYPE 2' named entity 'ESSENTIAL' named entity 'CONSERVED' named entity 'FRAGMENTS' named entity 'HUMORAL IMMUNE RESPONSE' named entity 'VIRUS' named entity 'LINEAR' named entity 'POTENTIAL' named entity 'HAVE' named entity 'STUDY' named entity 'INFECTED' named entity 'TO TEST' named entity 'UNIT' named entity 'MAB' named entity 'INVESTIGATED' named entity 'GENOME' named entity 'DESIGNATED' named entity 'TOOL' named entity 'INNATE IMMUNITY' named entity 'FOUND' named entity 'B-CELL EPITOPE' named entity 'PROTEIN ' named entity 'LOCALIZED' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'HTTPS' named entity '2F10' named entity 'HOST' named entity 'GENOTYPE 1'

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