About: Characteristics of lymphocyte subsets and their predicting values for the severity of COVID-19 patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characteristics of lymphocyte subsets and their predicting values for the severity of COVID-19 patients
Creator	Dong, Xingqi Li, Zhi Yang, Xinping Wang, Jingrong Xicheng, Zhang, Boting Zuo, Shuguang
source	MedRxiv
abstract	Severe COVID-19 patients showed worse clinical outcomes compared to mild and moderate patients. However, effective indicators are still lacking to predict the severity of the disease. In the present study, we retrospectively analyzed the clinical and laboratory data of 16 COVID-19 patients and found that the absolute counts of three T-cells (CD3+, CD4+, and CD8+) were significantly lower in the moderate and severe patients than those in mild patients and were significantly lower in severe patients than in moderate patients on admission. With the recovery of the COVID-19, serum levels of inflammatory biomarkers (CRP, PCT, and IL6) of moderate and severe patients gradually decreased. In contrast, the counts of lymphocytes and their subsets including CD3+, CD4+, and CD8+ T cells gradually increased in severe patients, and eventually showed comparable levels with moderate patients. ROC analysis showed that the counts of CD3+, CD4+, and CD8+ T-cells with AUC > 0.9 have potential values for predicting the severity of COVID-19 patients. In conclusion, the reduction of CD3+, CD4+, and CD8+ T-cells is related to the severity of COVID-19 and dynamic detection of these T-lymphocyte subsets may help predict the outcome of the patients.
has issue date	2020-05-05(xsd:dateTime)
bibo:doi	10.1101/2020.05.01.20086421
has license	medrxiv
sha1sum (hex)	c3e671130963eb7f8e0bf2c91caefffb2522a8c5
schema:url	https://doi.org/10.1101/2020.05.01.20086421
resource representing a document's title	Characteristics of lymphocyte subsets and their predicting values for the severity of COVID-19 patients
resource representing a document's body	covid:c3e671130963eb7f8e0bf2c91caefffb2522a8c5#body_text
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