About: Inhibition of Interferon-γ Signaling in Oligodendroglia Delays Coronavirus Clearance without Altering Demyelination

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About: Inhibition of Interferon-γ Signaling in Oligodendroglia Delays Coronavirus Clearance without Altering Demyelination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inhibition of Interferon-γ Signaling in Oligodendroglia Delays Coronavirus Clearance without Altering Demyelination
Creator	Atkinson, Roscoe Ramakrishna, Chandran Hoskin, Jason Bergmann, Cornelia Gonzá Lez,, John Hinton, David Macklin, Wendy Stohlman, Stephen
Source	Elsevier; Medline; PMC
abstract	Infection of the central nervous system (CNS) by the neurotropic JHM strain of mouse hepatitis virus (JHMV) induces an acute encephalomyelitis associated with demyelination. To examine the anti-viral and/or regulatory role of interferon-γ (IFN-γ) signaling in the cell that synthesizes and maintains the myelin sheath, we analyzed JHMV pathogenesis in transgenic mice expressing a dominant-negative IFN-γ receptor on oligodendroglia. Defective IFN-γ signaling was associated with enhanced oligodendroglial tropism and delayed virus clearance. However, the CNS inflammatory cell composition and CD8(+) T-cell effector functions were similar between transgenic and wild-type mice, supporting unimpaired peripheral and CNS immune responses in transgenic mice. Surprisingly, increased viral load in oligodendroglia did not affect the extent of myelin loss, the frequency of oligodendroglial apoptosis, or CNS recruitment of macrophages. These data demonstrate that IFN-γ receptor signaling is critical for the control of JHMV replication in oligodendroglia. In addition, the absence of a correlation between increased oligodendroglial infection and the extent of demyelination suggests a complex pathobiology of myelin loss in which infection of oligodendroglia is required but not sufficient.
has issue date	2006-03-01(xsd:dateTime)
bibo:doi	10.2353/ajpath.2006.050496
bibo:pmid	16507895
has license	bronze-oa
sha1sum (hex)	c3929f831bb6783e6fa725d871c804290e5307b3
schema:url	https://doi.org/10.2353/ajpath.2006.050496
resource representing a document's title	Inhibition of Interferon-γ Signaling in Oligodendroglia Delays Coronavirus Clearance without Altering Demyelination
has PubMed Central identifier	PMC1606538
has PubMed identifier	16507895
schema:publication	The American Journal of Pathology
resource representing a document's body	covid:c3929f831bb6783e6fa725d871c804290e5307b3#body_text
is schema:about of	named entity 'PERIPHERAL' named entity 'AFFECT' named entity 'MYELIN SHEATH' named entity 'VIRAL LOAD' named entity 'RECRUITMENT' named entity 'DATA' named entity 'ANALYZED' named entity 'CRITICAL' named entity 'RECEPTOR' named entity 'ABSENCE OF' named entity 'CONTROL' named entity 'CNS' named entity 'CD8' named entity '798' named entity 'IMMUNE RESPONSES' named entity 'COMPOSITION' named entity '168' named entity 'TRANSGENIC' named entity 'FUNCTIONS' named entity 'SIGNALING' named entity 'DOMINANT' named entity 'MACROPHAGES' named entity 'PATHOGENESIS' named entity 'T-CELL' named entity 'DID' named entity 'SUFFICIENT' named entity 'ASSOCIATED WITH' named entity 'NEGATIVE' named entity 'INCREASED' named entity 'IFN' named entity 'FREQUENCY' named entity 'DEMYELINATION' named entity 'APOPTOSIS' named entity 'REQUIRED' named entity 'ENHANCED' named entity 'TRANSGENIC MICE' named entity 'SIMILAR' named entity 'RECEPTOR SIGNALING' named entity 'VIRUS CLEARANCE' named entity 'LEZ' named entity 'SUPPORTING' named entity 'MYELIN LOSS' named entity 'THESE' named entity 'TROPISM' named entity 'EXTENT OF' named entity 'DOI' named entity 'OLIGODENDROGLIAL' named entity 'ADDITION' named entity 'INFLAMMATORY CELL' named entity 'COMPLEX' named entity 'PATHOBIOLOGY' named entity 'EFFECTOR' named entity 'DEFECTIVE' named entity 'INFECTION' named entity 'THE CELL' named entity '804' named entity 'BUT' named entity 'CORRELATION' named entity '90%' named entity 'REPLICATION' named entity 'MICE' named entity 'DELAYED' named entity 'OLIGODENDROGLIA' named entity 'GONZ' named entity 'WILD-TYPE' covid:arg/c3929f831bb6783e6fa725d871c804290e5307b3 named entity 'viral load' named entity 'correlation' named entity 'infection' named entity 'macrophages' named entity 'dominant-negative' named entity 'transgenic mice' named entity 'apoptosis' named entity 'oligodendroglia'

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