About: Lassa virus diversity and feasibility for universal prophylactic vaccine

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lassa virus diversity and feasibility for universal prophylactic vaccine
Creator	Paessler, Slobodan Carlos De La Torre, Juan Lukashevich, Igor
Source	Medline; PMC
abstract	Lassa virus (LASV) is a highly prevalent mammarenavirus in West Africa and is maintained in nature in a persistently infected rodent host, Mastomys natalensis, which is widely spread in sub-Saharan Africa. LASV infection of humans can cause Lassa fever (LF), a disease associated with high morbidity and significant mortality. Recent evidence indicates an LASV expansion outside its traditional endemic areas. In 2017, the World Health Organization (WHO) included LASV in top-priority pathogens and released a Target Product Profile (TPP) for vaccine development. Likewise, in 2018, the US Food and Drug Administration added LF to a priority review voucher program to encourage the development of preventive and therapeutics measures. In this article, we review recent progress in LASV vaccine research and development with a focus on the impact of LASV genetic and biological diversity on the design and development of vaccine candidates meeting the WHO’s TPP for an LASV vaccine.
has issue date	2019-01-31(xsd:dateTime)
bibo:doi	10.12688/f1000research.16989.1
bibo:pmid	30774934
has license	cc-by
sha1sum (hex)	c3617dc2a70b0046f95b857cb09cafeebf0a8ce4
schema:url	https://doi.org/10.12688/f1000research.16989.1
resource representing a document's title	Lassa virus diversity and feasibility for universal prophylactic vaccine
has PubMed Central identifier	PMC6357994
has PubMed identifier	30774934
schema:publication	F1000Res
resource representing a document's body	covid:c3617dc2a70b0046f95b857cb09cafeebf0a8ce4#body_text
is schema:about of	named entity 'TPP' named entity 'sub-Saharan Africa' named entity 'Food' named entity 'development' named entity 'APPROVED' named entity '2018' named entity 'MEASURES' named entity 'PROGRAM' named entity 'PREVENTIVE' named entity 'DISEASE ASSOCIATED' named entity 'EXPANSION' named entity 'RESEARCH AND DEVELOPMENT' named entity 'RECENT' named entity 'SUB-SAHARAN AFRICA' named entity 'GENETIC' named entity 'ADDED' named entity 'PATHOGENS' named entity 'DESIGN' named entity 'VACCINE RESEARCH' named entity 'HIGH' named entity '27S' named entity 'OUTSIDE' named entity 'FOOD AND DRUG ADMINISTRATION' named entity 'PRIORITY' named entity 'ASSOCIATED WITH' named entity 'FOCUS' named entity 'INFECTION' named entity 'CAUSE' named entity 'VOUCHER' named entity 'ITS' named entity 'VACCINE DEVELOPMENT' named entity 'HUMANS' named entity 'VACCINE' named entity 'RELEASED' named entity 'PRODUCT' named entity 'TPP' named entity 'TRADITIONAL' named entity 'LASSA VIRUS' named entity 'THERAPEUTICS' named entity 'PROGRESS' named entity 'AREAS' named entity 'UNIVERSAL' named entity 'PROPHYLACTIC VACCINE' named entity 'DIVERSITY' named entity 'ENDEMIC' named entity 'REVIEW' named entity 'PROFILE' named entity 'IMPACT' named entity 'TARGET' named entity 'LASSA FEVER' named entity 'WORLD HEALTH ORGANIZATION' named entity 'EVIDENCE' named entity 'DEVELOPMENT' named entity 'ARTICLE' named entity 'BIOLOGICAL DIVERSITY' named entity 'FEASIBILITY' named entity 'INCLUDED' named entity 'WIDELY SPREAD' named entity 'SIGNIFICANT' named entity 'MORTALITY' named entity 'MORBIDITY' named entity 'MEETING' named entity 'development' named entity 'mortality' named entity 'US Food and Drug Administration' named entity 'vaccine' named entity 'biological diversity' named entity 'sub-Saharan' named entity 'prophylactic' named entity 'reassortment' named entity 'IL-6' named entity 'CD8 +' named entity 'reassortants' named entity 'LASV' named entity 'exonuclease' named entity 'plasma' named entity 'vaccine' named entity 'VSV-G' named entity 'immunogenicity'

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