About: Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71

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About: Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71
Creator	Chang, Ching-Yao Hsiao, Nai-Wan Li, Shih-Wein Lin, Cheng-Wen Lin, Wei-Yong Lin, Ying-Ju Wan, Lei Wu, Chia-Fang
source	Elsevier; Medline; PMC
abstract	Abstract In this study, aloe-emodin was identified as a potential interferon (IFN)-inducer by screening compounds from Chinese herbal medicine. Aloe-emodin showed low cytotoxicity to human HL-CZ promonocyte cells and TE-671 medulloblastoma cells and significantly activated interferon-stimulated response element (ISRE) and gamma-activated sequence (GAS)-driven cis-reporting systems. Moreover, aloe-emodin upregulated expression of IFN-stimulated genes such as dsRNA-activated protein kinase and 2′,5′-oligoisoadenylate synthase. Aloe-emodin resulted in significant activation of nitric oxide production. The antiviral activity of aloe-emodin against Japanese encephalitis virus (JEV) and enterovirus 71 (EV71) was evaluated using dose- and time-dependent plaque reduction assays in HL-CZ cells and TE-671 cells. The 50% inhibitory concentration (IC50) of aloe-emodin ranged from 0.50μg/mL to 1.51μg/mL for JEV and from 0.14μg/mL to 0.52μg/mL for EV71. Aloe-emodin showed clearly potent virus inhibitory abilities and achieved high therapeutic indices, in particular for HL-CZ cells. Therefore, the study demonstrated dose- and time-dependent actions of aloe-emodin on the inhibition of JEV and EV71 replication via IFN signalling responses.
has issue date	2008-10-31(xsd:dateTime)
bibo:doi	10.1016/j.ijantimicag.2008.04.018
bibo:pmid	18701259
has license	els-covid
sha1sum (hex)	c35cfebd784ecfad6edd7d9d0e64386be447bbd4
schema:url	https://doi.org/10.1016/j.ijantimicag.2008.04.018
resource representing a document's title	Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71
has PubMed Central identifier	PMC7126984
has PubMed identifier	18701259
schema:publication	International Journal of Antimicrobial Agents
resource representing a document's body	covid:c35cfebd784ecfad6edd7d9d0e64386be447bbd4#body_text
is schema:about of	named entity 'AGENT' named entity 'JEV' named entity 'therapeutic indices' named entity 'INTERFERON' named entity 'IFN' named entity 'INHIBITION' named entity 'GENES' named entity 'ACTIVATED' named entity 'UPREGULATED EXPRESSION' named entity 'LOW' named entity 'INTERFERON-STIMULATED RESPONSE ELEMENT' named entity 'DEPENDENT' named entity 'STIMULATED' named entity 'INHIBITORY' named entity 'PARTICULAR' named entity 'CHINESE HERBAL MEDICINE' named entity 'ANTIVIRAL ACTIVITY' named entity 'INDUCER' named entity 'REDUCTION' named entity 'DSRNA' named entity 'MEDULLOBLASTOMA' named entity 'POTENTIAL' named entity 'ALOE-EMODIN' named entity 'STUDY' named entity 'THERAPEUTIC' named entity 'SYNTHASE' named entity 'DOSE' named entity 'CELLS' named entity 'SIGNALLING' named entity 'VIRUS' named entity 'ANTIVIRAL ACTIVITY' named entity 'PROMONOCYTE' named entity 'INTERFERON ' named entity 'SCREENING' named entity 'ENTEROVIRUS 71' named entity '0.14' named entity 'ABILITIES' named entity 'PROTEIN KINASE' named entity 'REPLICATION' named entity 'CONCENTRATION' named entity '50%' named entity 'TIME' named entity 'REPORTING' named entity 'HIGH' named entity 'HUMAN' named entity 'CIS' named entity 'IDENTIFIED' named entity 'PLAQUE' covid:arg/c35cfebd784ecfad6edd7d9d0e64386be447bbd4 named entity 'USING' named entity '2C5' named entity 'EVALUATED' named entity 'JAPANESE ENCEPHALITIS VIRUS' named entity 'INDUCING' named entity 'CYTOTOXICITY' named entity 'SYSTEMS' named entity 'TE-671' named entity 'RESPONSES' named entity 'DRIVEN' named entity 'SIGNIFICANT' named entity 'SEQUENCE' named entity 'NITRIC OXIDE PRODUCTION' named entity 'JAPANESE ENCEPHALITIS VIRUS' named entity 'ACTIONS' named entity 'ACTIVATION' named entity 'ALOE-EMODIN' named entity 'ENTEROVIRUS 71' named entity 'INDICES' named entity 'enterovirus' named entity 'Therefore' named entity 'evaluated' named entity 'JEV' named entity 'cells' named entity 'interferon'

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