About: Infection of Human Airway Epithelia with H1N1, H2N2, and H3N2 Influenza A Virus Strains

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About: Infection of Human Airway Epithelia with H1N1, H2N2, and H3N2 Influenza A Virus Strains Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infection of Human Airway Epithelia with H1N1, H2N2, and H3N2 Influenza A Virus Strains
Creator	Wang, Guoshun Davidson, Beverly Mccray, Paul Slepushkin, Vladimir Staber, Patrick
Source	Elsevier; Medline; PMC
abstract	Three subtypes of influenza A virus cause human disease: H1N1, H2N2, and H3N2. Although all result in respiratory illness, little is known about how these subtypes infect differentiated airway epithelia. Therefore, we assayed A/PR/8/34 (H1N1), A/Japan/305/57 (H2N2), and X31 (H3N2) influenza virus strains for binding and infection on fully differentiated primary cultures of airway epithelia isolated from human bronchus, grown on semiporous filters at an air–liquid interface. In this model system, viral infectivity was highest when virus was applied to the apical versus the basolateral surface; Japan was most infectious, followed by PR8. The X31 strain showed very low levels of infectivity. Confocal microscopy and fluorescence-resonance energy transfer studies indicated that Japan virus could enter and fuse with cellular membranes, while infection with X31 virions was greatly inhibited. Japan virus could also productively infect human trachea explant tissues. These data show that influenza viruses with SAα2,3Gal binding specificity, like Japan, productively infect differentiated human airway epithelia from the apical surface. These data are important to consider in the development of pseudotyped recombinant viral vectors for gene transfer to human airway epithelia for gene therapy.
has issue date	2016-12-14(xsd:dateTime)
bibo:doi	10.1006/mthe.2001.0277
bibo:pmid	11273782
has license	no-cc
sha1sum (hex)	c348e752bd75d70836f7b24f4d77f59c3e2ae366
schema:url	https://doi.org/10.1006/mthe.2001.0277
resource representing a document's title	Infection of Human Airway Epithelia with H1N1, H2N2, and H3N2 Influenza A Virus Strains
has PubMed Central identifier	PMC7106098
has PubMed identifier	11273782
schema:publication	Mol Ther
resource representing a document's body	covid:c348e752bd75d70836f7b24f4d77f59c3e2ae366#body_text
is schema:about of	named entity 'Japan' named entity 'influenza' named entity 'virions' named entity 'differentiated' named entity 'infectivity' named entity 'levels' named entity 'H1N1' named entity 'infection' named entity 'epithelia' named entity 'Virus' named entity 'H2N2' named entity 'Influenza A' named entity 'Airway' named entity 'H1N1' named entity 'HUMAN' named entity 'H2N2' named entity 'STRAINS' named entity 'LIKE' named entity 'JAPAN' named entity 'APICAL' named entity 'BASOLATERAL' named entity 'ISOLATED' named entity 'FLUORESCENCE' named entity 'INFECT' named entity 'INTERFACE' named entity 'INFECTION' named entity 'RECOMBINANT' named entity 'HUMAN DISEASE' named entity 'MEMBRANES' named entity 'PR8' named entity 'FUSE' named entity 'DIFFERENTIATED' named entity 'DEVELOPMENT' covid:arg/c348e752bd75d70836f7b24f4d77f59c3e2ae366 named entity 'INFECTION' named entity 'VIRUS' named entity 'RESULT' named entity 'BRONCHUS' named entity 'TISSUES' named entity 'H3N2 INFLUENZA' named entity 'AIRWAY' named entity 'STRAINS' named entity 'APICAL SURFACE' named entity '2F8' named entity 'FOLLOWED BY' named entity 'PRIMARY CULTURES' named entity 'VIRAL' named entity 'GENE THERAPY' named entity 'INHIBITED' named entity 'H3N2' named entity 'VIRIONS' named entity 'GENE TRANSFER' named entity 'KNOWN' named entity 'STUDIES' named entity 'AIR-LIQUID' named entity 'INFLUENZA A VIRUS' named entity 'TRACHEA' named entity 'HUMAN' named entity 'INFLUENZA A VIRUS' named entity 'INFLUENZA VIRUSES' named entity 'IMPORTANT' named entity 'CONFOCAL MICROSCOPY' named entity 'APPLIED' named entity 'SURFACE' named entity 'HOW' named entity '90%' named entity 'VIRAL VECTORS' named entity 'RESPIRATORY ILLNESS' named entity 'STRAIN' named entity 'H1N1' named entity 'X31' named entity 'H2N2' named entity 'MODEL SYSTEM' named entity 'RESONANCE ENERGY TRANSFER' named entity 'INFECTIOUS' named entity 'HIGHEST' named entity 'THESE'

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