About: Geographical distribution of complement receptor type 1 variants and their associated disease risk

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About: Geographical distribution of complement receptor type 1 variants and their associated disease risk Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Geographical distribution of complement receptor type 1 variants and their associated disease risk
Creator	Ntoumi, Francine Kremsner, Peter Thangaraj, Kumarasamy Antunes Andrade, Fabiana Elumalai, Preetham Meyer, Christian Adukpo, Dao, Phuong Giang, Jose De Messias Reason, Iara Lakshmi Valluri, Vijaya Nguetse, Christian Sandri, Thaisa Song, Le Toan, Nguyen Van Tong, Hoang Velavan, Thirumalaisamy
topic	covid:c32d0c0e6f09f6da1b8d9075733574b26bfec04a#this
Source	Medline; PMC
abstract	BACKGROUND: Pathogens exert selective pressure which may lead to substantial changes in host immune responses. The human complement receptor type 1 (CR1) is an innate immune recognition glycoprotein that regulates the activation of the complement pathway and removes opsonized immune complexes. CR1 genetic variants in exon 29 have been associated with expression levels, C1q or C3b binding and increased susceptibility to several infectious diseases. Five distinct CR1 nucleotide substitutions determine the Knops blood group phenotypes, namely Kn(a/b), McC(a/b), Sl1/Sl2, Sl4/Sl5 and KCAM+/-. METHODS: CR1 variants were genotyped by direct sequencing in a cohort of 441 healthy individuals from Brazil, Vietnam, India, Republic of Congo and Ghana. RESULTS: The distribution of the CR1 alleles, genotypes and haplotypes differed significantly among geographical settings (p≤0.001). CR1 variants rs17047660A/G (McC(a/b)) and rs17047661A/G (Sl1/Sl2) were exclusively observed to be polymorphic in African populations compared to the groups from Asia and South-America, strongly suggesting that these two SNPs may be subjected to selection. This is further substantiated by a high linkage disequilibrium between the two variants in the Congolese and Ghanaian populations. A total of nine CR1 haplotypes were observed. The CR1AGAATA haplotype was found more frequently among the Brazilian and Vietnamese study groups; the CR1AGAATG haplotype was frequent in the Indian and Vietnamese populations, while the CR1*AGAGTG haplotype was frequent among Congolese and Ghanaian individuals. CONCLUSION: The African populations included in this study might have a selective advantage conferred to immune genes involved in pathogen recognition and signaling, possibly contributing to disease susceptibility or resistance.
has issue date	2017-05-17(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0175973
bibo:pmid	28520715
has license	cc-by
sha1sum (hex)	c32d0c0e6f09f6da1b8d9075733574b26bfec04a
schema:url	https://doi.org/10.1371/journal.pone.0175973
resource representing a document's title	Geographical distribution of complement receptor type 1 variants and their associated disease risk
has PubMed Central identifier	PMC5435133
has PubMed identifier	28520715
schema:publication	PLoS One
resource representing a document's body	covid:c32d0c0e6f09f6da1b8d9075733574b26bfec04a#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/c32d0c0e6f09f6da1b8d9075733574b26bfec04a
is schema:about of	named entity 'CR1' named entity 'regulates' named entity 'complement pathway' named entity 'distribution' covid:arg/c32d0c0e6f09f6da1b8d9075733574b26bfec04a named entity 'blood group' named entity 'host' named entity 'opsonized' named entity 'substitutions' named entity 'phenotypes' named entity 'determine' named entity 'nucleotide' named entity 'levels' named entity 'expression' named entity 'risk' named entity 'genetic variants' named entity 'phenotypes' named entity 'nucleotide substitutions' named entity 'expression levels' named entity 'opsonized' named entity 'C3b' named entity 'complement pathway' named entity 'CR1' named entity 'selective pressure' named entity 'type 1' named entity 'host cells' named entity 'downregulate' named entity 'exon' named entity 'adaptive immune responses' named entity 'CR1' named entity 'malaria' named entity 'gene' named entity 'immune complexes' named entity 'CR1' named entity 'allele' named entity 'Hilden' named entity 'haplotype' named entity 'homologous' named entity 'CR1' named entity 'PCR' named entity 'polymorphic' named entity 'CR1' named entity 'protein' named entity 'Cognitive decline' named entity 'monomorphic' named entity 'exon' named entity 'La Jolla' named entity 'denaturation' named entity 'genomic DNA' named entity 'antigens' named entity 'immune responses' named entity 'SNPs' named entity 'haplotype' named entity 'blood group' named entity 'Linkage disequilibrium' named entity 'Asia' named entity 'denaturation' named entity 'selective pressure' named entity 'Africa' named entity 'antigen' named entity 'CR1' named entity 'McC' named entity 'intracellular pathogens'

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