About: The Antiviral and Antitumor Effects of Defective Interfering Particles/Genomes and Their Mechanisms

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Antiviral and Antitumor Effects of Defective Interfering Particles/Genomes and Their Mechanisms
Creator	Xie, Qian Zhang, Bao Zhao, Wei He, Xiaoen Chen, Tingting Wu, Qinghua Lyu, Taibiao Shen, Chu Yang, Yicheng Ye, Kaiyan Zhou, Runing Chattopadhyay, Saurabh Li, Zhu Aras, Siddhesh
Source	Medline; PMC
abstract	Defective interfering particles (DIPs), derived naturally from viral particles, are not able to replicate on their own. Several studies indicate that DIPs exert antiviral effects via multiple mechanisms. DIPs are able to activate immune responses and suppress virus replication cycles, such as competing for viral replication products, impeding the packaging, release and invasion of viruses. Other studies show that DIPs can be used as a vaccine against viral infection. Moreover, DIPs/DI genomes display antitumor effects by inducing tumor cell apoptosis and promoting dendritic cell maturation. With genetic modified techniques, it is possible to improve its safety against both viruses and tumors. In this review, a comprehensive discussion on the effects exerted by DIPs is provided. We further highlight the clinical significance of DIPs and propose that DIPs can open up a new platform for antiviral and antitumor therapies.
has issue date	2019-08-09(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.01852
bibo:pmid	31447826
has license	cc-by
sha1sum (hex)	c32c30f41c1f50f242b977297a8ff85eda1a2987
schema:url	https://doi.org/10.3389/fmicb.2019.01852
resource representing a document's title	The Antiviral and Antitumor Effects of Defective Interfering Particles/Genomes and Their Mechanisms
has PubMed Central identifier	PMC6696905
has PubMed identifier	31447826
schema:publication	Front Microbiol
resource representing a document's body	covid:c32c30f41c1f50f242b977297a8ff85eda1a2987#body_text
is schema:about of	named entity 'MECHANISMS' named entity 'MULTIPLE' named entity 'STUDIES' named entity 'EXERT' named entity 'SUPPRESS' named entity 'APOPTOSIS' named entity 'ACTIVATE' named entity 'TUMOR CELL' named entity 'DISCUSSION' named entity 'TUMORS' named entity 'ANTIVIRAL' named entity 'INDUCING' named entity 'DERIVED' named entity 'DENDRITIC CELL MATURATION' named entity 'PLATFORM' named entity 'GENOMES' named entity 'CLINICAL SIGNIFICANCE' named entity 'MECHANISMS' named entity 'NEW' named entity 'RELEASE' named entity 'VIRAL INFECTION' named entity 'PROVIDED' named entity 'EFFECTS' named entity 'REPLICATE' named entity 'EXERTED' named entity 'DISPLAY' named entity 'REVIEW' named entity 'THEIR' named entity 'ANTITUMOR' named entity 'OPEN' named entity 'VIRAL REPLICATION' named entity 'POSSIBLE' named entity 'THEIR' named entity 'PRODUCTS' named entity 'PACKAGING' named entity 'VACCINE' named entity 'ANTITUMOR' named entity 'COMPREHENSIVE' named entity 'IMMUNE RESPONSES' named entity 'EFFECTS' named entity 'CITATION' named entity 'ANTIVIRAL' named entity 'SAFETY' named entity 'TECHNIQUES' named entity 'GENETIC' named entity 'USED' named entity 'PROMOTING' named entity 'INVASION' named entity 'VIRUSES' named entity 'IMPEDING' named entity 'MODIFIED' named entity 'THERAPIES' named entity 'DEFECTIVE INTERFERING PARTICLES' named entity 'DEFECTIVE INTERFERING PARTICLES' named entity 'VIRAL PARTICLES' named entity 'VIRUS REPLICATION' named entity 'ITS' covid:arg/c32c30f41c1f50f242b977297a8ff85eda1a2987 named entity 'dendritic cell' named entity 'antiviral' named entity 'antiviral' named entity 'genomes' named entity 'Antitumor' named entity 'genomes' named entity 'antiviral' named entity 'DCs' named entity 'heterologous' named entity 'apoptotic effects'

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