About: Quorum sensing affects virulence-associated proteins F1, LcrV, KatY and pH6 etc. of Yersinia pestis as revealed by protein microarray-based antibody profiling

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About: Quorum sensing affects virulence-associated proteins F1, LcrV, KatY and pH6 etc. of Yersinia pestis as revealed by protein microarray-based antibody profiling Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Quorum sensing affects virulence-associated proteins F1, LcrV, KatY and pH6 etc. of Yersinia pestis as revealed by protein microarray-based antibody profiling
Creator	Li, Bei Yang, Ruifu Han, Yanping Chen, Zeliang Du, Zongmin Guo, Zhaobiao Zhou, Dongsheng Qin, Long Song, Yajun Zhang, Jianshan
Source	Elsevier; Medline; PMC
abstract	Protein microarray that consists of virulence-associated proteins of Yersinia pestis is used to compare antibody profiles elicited by the wild-type and quorum sensing (QS) mutant strain of this bacterium to define the immunogens that are impacted by QS. The results will lead the way for future functional proteomics studies. The antibody profile that was induced by the QS mutant differed from that of the parent strain. Detailed comparison of the antibody profiles, according to the proteins’ functional annotations, showed that QS affects the expression of many virulence-associated proteins of Y. pestis. The antibodies to many virulence-associated proteins were not detected or lower titers of antibodies to many proteins were detected in the sera of rabbits immunized with the QS mutant, relative to those of the wild type, which indicated that these proteins were not expressed or expressed at relatively lower levels in the QS mutant. The results demonstrated that antibody profiling by protein microarrays is a promising high-throughput method for revealing the interactions between pathogens and the host immune system.
has issue date	2006-07-28(xsd:dateTime)
bibo:doi	10.1016/j.micinf.2006.06.007
bibo:pmid	16997598
has license	no-cc
sha1sum (hex)	c2aedc38ec54bfe4e7aa93515bb1a683c8b6c1a3
schema:url	https://doi.org/10.1016/j.micinf.2006.06.007
resource representing a document's title	Quorum sensing affects virulence-associated proteins F1, LcrV, KatY and pH6 etc. of Yersinia pestis as revealed by protein microarray-based antibody profiling
has PubMed Central identifier	PMC7110770
has PubMed identifier	16997598
schema:publication	Microbes Infect
resource representing a document's body	covid:c2aedc38ec54bfe4e7aa93515bb1a683c8b6c1a3#body_text
is schema:about of	named entity 'antibodies' named entity 'Y. pestis' named entity 'proteins' named entity 'revealing' named entity 'interactions' named entity 'sera' named entity 'protein' named entity 'define' named entity 'lead' named entity 'BASED' named entity 'ANTIBODY' named entity 'LCRV' named entity 'DETAILED' named entity 'PARENT' named entity 'USED' named entity 'WILDTYPE' named entity 'TO COMPARE' named entity 'IMMUNIZED' named entity 'FUNCTIONAL PROTEOMICS' named entity 'ANTIBODY' named entity 'COMPARISON' named entity 'LEVELS' named entity 'WILD TYPE' named entity 'EXPRESSED' named entity 'LOWER' named entity 'LEAD' named entity 'ANNOTATIONS' named entity 'IMMUNE SYSTEM' named entity 'PROTEINS' named entity 'ANTIBODIES' named entity 'IS A' named entity 'KATY' named entity 'REVEALING' named entity 'THROUGHPUT' named entity 'FUTURE' named entity 'INDICATED' named entity 'IMPACTED' named entity 'PROTEIN MICROARRAYS' named entity 'RELATIVE TO' named entity 'PATHOGENS' named entity 'ACCORDING' named entity 'RESULTS' named entity 'ANTIBODY PROFILE' named entity 'INTERACTIONS' named entity 'BACTERIUM' named entity 'WAY' named entity 'EXPRESSION' named entity 'QUORUM SENSING' named entity 'PROTEIN MICROARRAY' named entity 'ASSOCIATED' named entity 'HIGH' named entity 'STUDIES' named entity 'QUORUM SENSING' named entity 'THESE' named entity 'REVEALED' named entity 'VIRULENCE' named entity 'YERSINIA PESTIS' named entity 'PROTEINS' named entity 'ASSOCIATED' named entity 'IMMUNOGENS' named entity 'YERSINIA PESTIS' named entity 'HOST' named entity 'ETC.' named entity 'INDUCED' named entity 'DETECTED' named entity 'MUTANT STRAIN' named entity 'PROTEIN MICROARRAY' named entity 'DEMONSTRATED' named entity 'STRAIN' named entity 'NOT DETECTED' named entity 'VIRULENCE' named entity 'SERA'

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