About: Detection of viral respiratory pathogens in mild and severe acute respiratory infections in Singapore

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Detection of viral respiratory pathogens in mild and severe acute respiratory infections in Singapore
Creator	Cui, Lin Leo, Yee-Sin Chen, Mark I-Cheng Hibberd, Martin Jiang, Lili Lin, Raymond Low, Louie Lim, Wei-Yen Lin Tan, Linda Jian, Vernon Lee, Ming Lin Tan, Chyi
Source	Medline; PMC
abstract	To investigate the performance of laboratory methods and clinical case definitions in detecting the viral pathogens for acute respiratory infections (ARIs) from a prospective community cohort and hospital inpatients, nasopharyngeal swabs from cohort members reporting ARIs (community-ARI) and inpatients admitted with ARIs (inpatient-ARI) were tested by Singleplex Real Time-Polymerase Chain Reaction (SRT-PCR), multiplex RT-PCR (MRT-PCR) and pathogen-chip system (PathChip) between April 2012 and December 2013. Community-ARI and inpatient-ARI was also combined with mild and severe cases of influenza from a historical prospective study as mild-ARI and severe-ARI respectively to evaluate the performance of clinical case definitions. We analysed 130 community-ARI and 140 inpatient-ARI episodes (5 inpatient-ARI excluded because multiple pathogens were detected), involving 138 and 207 samples respectively. Detection by PCR declined with days post-onset for influenza virus; decrease was faster for community-ARI than for inpatient-ARI. No such patterns were observed for non-influenza respiratory virus infections. PathChip added substantially to viruses detected for community-ARI only. Clinical case definitions discriminated influenza from other mild-ARI but performed poorly for severe-ARI and for older participants. Rational strategies for diagnosis and surveillance of influenza and other respiratory virus must acknowledge the differences between ARIs presenting in community and hospital settings.
has issue date	2017-02-20(xsd:dateTime)
bibo:doi	10.1038/srep42963
bibo:pmid	28218288
has license	cc-by
sha1sum (hex)	c29e836db0541b34ffaf6a75c8b7079fd98220d8
schema:url	https://doi.org/10.1038/srep42963
resource representing a document's title	Detection of viral respiratory pathogens in mild and severe acute respiratory infections in Singapore
has PubMed Central identifier	PMC5317157
has PubMed identifier	28218288
schema:publication	Sci Rep
resource representing a document's body	covid:c29e836db0541b34ffaf6a75c8b7079fd98220d8#body_text
is schema:about of	named entity 'COMMUNITY' named entity 'POLYMERASE CHAIN REACTION' named entity 'ACUTE RESPIRATORY INFECTIONS' named entity 'diagnosis' named entity 'patterns' named entity 'excluded' named entity 'prospective' named entity 'nasopharyngeal' named entity 'PROSPECTIVE' named entity 'VIRAL' named entity 'SEVERE' named entity 'ARI' named entity 'ADMITTED' named entity 'DETECTED' named entity 'PATHOGENS' named entity 'SAMPLES' named entity 'EXCLUDED' named entity 'PROSPECTIVE STUDY' named entity 'ARI' named entity 'POST' named entity 'HISTORICAL' named entity 'VIRUSES' named entity 'INFLUENZA VIRUS' named entity 'PATTERNS' named entity 'BUT' named entity 'EPISODES' named entity 'FASTER' named entity 'DAYS' named entity 'MULTIPLE' named entity 'SURVEILLANCE' named entity 'INFLUENZA' named entity 'NASOPHARYNGEAL' named entity 'TO INVESTIGATE' named entity 'CHIP' named entity 'PERFORMANCE' named entity 'PCR' named entity 'ADDED' named entity 'CASES' named entity 'SETTINGS' named entity 'CLINICAL' named entity 'PRESENTING' named entity 'CLINICAL' named entity 'DECREASE' named entity 'DETECTING' named entity 'DETECTION' named entity 'SINGAPORE' named entity 'CASE' named entity 'MILD' named entity 'PATHOGEN' named entity 'INVOLVING' named entity 'MULTIPLEX' named entity 'RT-PCR' named entity 'OPEN' named entity 'INPATIENTS' named entity 'COHORT' named entity 'REPORTING' named entity 'VIRAL PATHOGENS' named entity 'REAL TIME' named entity 'RESPIRATORY PATHOGENS' named entity 'TESTED' named entity 'POORLY' named entity 'PARTICIPANTS' named entity 'INPATIENT' named entity 'RESPIRATORY VIRUS' named entity 'EVALUATE' named entity 'SEVERE' named entity 'STRATEGIES' named entity 'MILD' named entity 'DETECTION' named entity 'HOSPITAL'

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