About: Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease

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About: Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease
Creator	Luo, Rui Xiao, Shaobo Zhao, Ling Peng, Guiqing Shen, Zhou Ye, Gang Deng, Feng Fu, Zhen
Source	Elsevier; Medline; PMC
abstract	Abstract Porcine epidemic diarrhea virus (PEDV), a member of the genus Alphacoronavirus, has caused significant damage to the Asian and American pork industries. Coronavirus 3C-like protease (3CLpro), which is involved in the processing of viral polyproteins for viral replication, is an appealing antiviral drug target. Here, we present the crystal structures of PEDV 3CLpro and a molecular complex between an inactive PEDV 3CLpro variant C144A bound to a peptide substrate. Structural characterization, mutagenesis and biochemical analysis reveal the substrate-binding pockets and the residues that comprise the active site of PEDV 3CLpro. The dimerization of PEDV 3CLpro is similar to that of other Alphacoronavirus 3CLpros but has several differences from that of SARS-CoV 3CLpro from the genus Betacoronavirus. Furthermore, the non-conserved motifs in the pockets cause different cleavage of substrate between PEDV and SARS-CoV 3CLpros, which may provide new insights into the recognition of substrates by 3CLpros in various coronavirus genera.
has issue date	2016-07-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2016.04.018
bibo:pmid	27128350
has license	els-covid
sha1sum (hex)	c28f76835909d9556c4f74299605c398ed79e25b
schema:url	https://doi.org/10.1016/j.virol.2016.04.018
resource representing a document's title	Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease
has PubMed Central identifier	PMC7111274
has PubMed identifier	27128350
schema:publication	Virology
resource representing a document's body	covid:c28f76835909d9556c4f74299605c398ed79e25b#body_text
is schema:about of	named entity 'SPECIFICITY' named entity 'polyproteins' named entity 'molecular complex' named entity 'CAUSED' named entity 'VIRAL' named entity 'CORONAVIRUS' named entity 'GENUS BETACORONAVIRUS' named entity 'BINDING' named entity 'ACTIVE SITE' named entity 'S IN' named entity 'DAMAGE' named entity 'HERE' named entity 'AMERICAN' named entity 'PRO' named entity 'MUTAGENESIS' named entity 'BUT' named entity 'ALPHACORONAVIRUS' named entity 'PRESENT' named entity 'INVOLVED' named entity 'PROCESSING' named entity 'PROTEASE' named entity 'NEW' named entity 'BIOCHEMICAL ANALYSIS' named entity 'SARS-COV' named entity 'STRUCTURAL CHARACTERIZATION' named entity 'APPEALING' named entity 'INACTIVE' named entity 'BOUND' named entity 'INDUSTRIES' named entity 'MOLECULAR COMPLEX' named entity 'SIMILAR' named entity 'PROVIDE' named entity 'DIMERIZATION' named entity 'MOTIFS' named entity 'CAUSE' named entity 'NON-' named entity 'DRUG TARGET' named entity 'DIFFERENT' named entity 'ANTIVIRAL DRUG' named entity 'CLEAVAGE' named entity 'VARIANT' named entity 'PORK' named entity 'PROTEASE' named entity 'ASIAN' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'MEMBER OF' named entity 'CONSERVED' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'DIMERIZATION' named entity 'SUBSTRATE RECOGNITION' named entity 'BASIS' named entity 'STRUCTURAL' named entity 'LIKE' named entity 'GENUS ALPHACORONAVIRUS' named entity 'STRUCTURES' named entity 'SITE OF' named entity 'CRYSTAL' named entity 'REVEAL' named entity 'VARIOUS' named entity 'INSIGHTS' named entity 'POLYPROTEINS' named entity 'COMPRISE' named entity 'SUBSTRATE' named entity 'PEPTIDE' named entity 'RECOGNITION' named entity 'VIRAL REPLICATION' named entity 'LIKE' named entity 'SIGNIFICANT' covid:arg/c28f76835909d9556c4f74299605c398ed79e25b named entity 'dimerization' named entity 'viral replication' named entity 'SARS-CoV' named entity 'pork' named entity 'antiviral drug'

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