About: Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model

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About: Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model
Creator	Munster, Vincent Bushmaker, Trenton Lambe, Teresa Saturday, Greg Wells, Daniel Wright, Daniel Fischer, Robert Gilbert, Sarah Warimwe, George De Wit, Emmie Van Doremalen, Neeltje
Source	Medline; PMC
abstract	Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic virus that causes severe respiratory disease in humans with a case fatality rate close to 40%, but for which no vaccines are available. Here, we evaluated the utility of ChAdOx1, a promising replication-deficient simian adenovirus vaccine vector platform with an established safety profile in humans and dromedary camels, for MERS-CoV vaccine development. Using a transgenic lethal BALB/c MERS-CoV mouse model we showed that single dose intranasal or intramuscular immunisation with ChAdOx1 MERS, encoding full-length MERS-CoV Spike glycoprotein, is highly immunogenic and confers protection against lethal viral challenge. Immunogenicity and efficacy were comparable between immunisation routes. Together these data provide support for further evaluation of ChAdOx1 MERS vaccine in humans and dromedary camels, the animal reservoir of infection.
has issue date	2017-10-16(xsd:dateTime)
bibo:doi	10.1038/s41541-017-0029-1
bibo:pmid	29263883
has license	cc-by
sha1sum (hex)	c28845dc44f29502a6012256075760eab1d62af0
schema:url	https://doi.org/10.1038/s41541-017-0029-1
resource representing a document's title	Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model
has PubMed Central identifier	PMC5643297
has PubMed identifier	29263883
schema:publication	NPJ Vaccines
resource representing a document's body	covid:c28845dc44f29502a6012256075760eab1d62af0#body_text
is schema:about of	named entity 'EFFICACY' named entity 'routes' named entity 'intramuscular' named entity 'glycoprotein' named entity 'transgenic' named entity 'human' named entity 'MERS-CoV' named entity 'REPLICATION' named entity 'THESE' named entity 'CAUSES' named entity 'MERS VACCINE' named entity 'DEFICIENT' named entity 'VACCINES' named entity 'SEVERE' named entity 'HERE' named entity 'DOSE' named entity 'VIRAL' named entity 'ROUTES' named entity 'CASE FATALITY RATE' named entity 'LENGTH' named entity 'BUT' named entity 'LETHAL' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'UTILITY' named entity 'INTRANASAL' named entity 'MERS' named entity 'AVAILABLE' named entity 'HUMANS' named entity 'INFECTION' named entity 'ZOONOTIC' named entity 'BALB' named entity 'HIGHLY' named entity 'ENCODING' named entity 'PROTECTION' named entity 'EFFICACY' named entity 'IS A' named entity 'NOVEL' named entity 'MOUSE MODEL' named entity 'CLOSE TO' covid:arg/c28845dc44f29502a6012256075760eab1d62af0 named entity 'ANIMAL' named entity '40%' named entity 'EVALUATION' named entity 'TRANSGENIC' named entity 'CHALLENGE' named entity 'SAFETY' named entity 'LETHAL' named entity 'NOVEL' named entity 'HUMAN' named entity 'ADENOVIRUS VACCINE' named entity 'DPP4' named entity 'USING' named entity 'RESPIRATORY DISEASE' named entity 'SIMIAN ADENOVIRUS' named entity 'PLATFORM' named entity 'MOUSE MODEL' named entity 'PROFILE' named entity 'ESTABLISHED' named entity 'SINGLE' named entity 'PROVIDE' named entity 'IMMUNOGENIC' named entity 'VIRUS' named entity 'RESERVOIR' named entity 'CHALLENGE' named entity 'CAMELS' named entity 'INTRAMUSCULAR' named entity 'ADENOVIRUS VACCINE VECTOR' named entity 'EVALUATED' named entity 'MERS-COV' named entity 'SIMIAN ADENOVIRUS' named entity 'DROMEDARY'

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