About: Domain-Swapped Structure of the Potent Antiviral Protein Griffithsin and Its Mode of Carbohydrate Binding

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About: Domain-Swapped Structure of the Potent Antiviral Protein Griffithsin and Its Mode of Carbohydrate Binding Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Domain-Swapped Structure of the Potent Antiviral Protein Griffithsin and Its Mode of Carbohydrate Binding
Creator	Vojdani, Fakhrieh Giomarelli, Barbara Mori, Toshiyuki Wlodawer, Alexander Zhu, Charles Mcmahon, James O'keefe, Barry Palmer, Kenneth Zió Łkowska, Natasza
Source	Elsevier; Medline; PMC
abstract	Summary The crystal structure of griffithsin, an antiviral lectin from the red alga Griffithsia sp., was solved and refined at 1.3 Å resolution for the free protein and 0.94 Å for a complex with mannose. Griffithsin molecules form a domain-swapped dimer, in which two β strands of one molecule complete a β prism consisting of three four-stranded sheets, with an approximate 3-fold axis, of another molecule. The structure of each monomer bears close resemblance to jacalin-related lectins, but its dimeric structure is unique. The structures of complexes of griffithsin with mannose and N-acetylglucosamine defined the locations of three almost identical carbohydrate binding sites on each monomer. We have also shown that griffithsin is a potent inhibitor of the coronavirus responsible for severe acute respiratory syndrome (SARS). Antiviral potency of griffithsin is likely due to the presence of multiple, similar sugar binding sites that provide redundant attachment points for complex carbohydrate molecules present on viral envelopes.
has issue date	2006-07-31(xsd:dateTime)
bibo:doi	10.1016/j.str.2006.05.017
bibo:pmid	16843894
has license	els-covid
sha1sum (hex)	c2732f1806306f0cab041609b3115dbd982ce3a3
schema:url	https://doi.org/10.1016/j.str.2006.05.017
resource representing a document's title	Domain-Swapped Structure of the Potent Antiviral Protein Griffithsin and Its Mode of Carbohydrate Binding
has PubMed Central identifier	PMC7126681
has PubMed identifier	16843894
schema:publication	Structure
resource representing a document's body	covid:c2732f1806306f0cab041609b3115dbd982ce3a3#body_text
is schema:about of	named entity 'PROTEIN ' named entity 'complex carbohydrate' named entity 'potent' named entity 'multiple' named entity 'Structure' named entity 'Binding' named entity 'Antiviral' named entity 'SIMILAR' named entity '1.3' named entity 'CLOSE' named entity 'COMPLEX CARBOHYDRATE' named entity 'MANNOSE' named entity 'BUT' named entity 'AXIS' named entity 'COMPLEXES' named entity 'ITS' named entity 'DEFINED' named entity 'DIMER' named entity 'VIRAL' named entity 'CARBOHYDRATE BINDING' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'ALMOST' named entity 'MODE' named entity 'ANTIVIRAL' named entity 'ITS' named entity 'DOMAIN' named entity 'IDENTICAL' named entity 'FOLD' named entity 'FREE' named entity 'RESPONSIBLE' named entity 'CARBOHYDRATE BINDING' named entity 'STRUCTURE' named entity 'STRUCTURES' named entity 'MONOMER' named entity 'MOLECULES' named entity 'BINDING SITES' named entity 'FORM' named entity 'LIKELY' named entity 'PRESENCE OF' named entity 'PROVIDE' named entity 'UNIQUE' named entity 'RED' named entity 'GRIFFITHSIA' named entity 'ALGA' named entity 'MULTIPLE' named entity 'CORONAVIRUS' named entity 'POTENCY' named entity 'COMPLETE' named entity 'STRUCTURE' named entity 'BEARS' named entity 'OF EACH' named entity 'REDUNDANT' named entity 'CRYSTAL STRUCTURE' named entity 'PRESENT' named entity 'ATTACHMENT' named entity 'MOLECULE' named entity 'POINTS' named entity 'RESOLUTION' named entity 'HAVE' named entity 'LECTINS' named entity 'N-ACETYLGLUCOSAMINE' named entity 'CARBOHYDRATE MOLECULES' named entity 'DUE TO' named entity 'RESEMBLANCE' named entity 'LOCATIONS' named entity 'IS A' named entity 'COMPLEX' named entity '0.94' named entity 'RELATED' named entity 'APPROXIMATE' named entity 'INHIBITOR' named entity 'DOMAIN' named entity 'JACALIN'

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