About: Identification of Aedes aegypti Long Intergenic Non-coding RNAs and Their Association with Wolbachia and Dengue Virus Infection

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About: Identification of Aedes aegypti Long Intergenic Non-coding RNAs and Their Association with Wolbachia and Dengue Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification of Aedes aegypti Long Intergenic Non-coding RNAs and Their Association with Wolbachia and Dengue Virus Infection
Creator	Asgari, Sassan Etebari, Kayvan Zhang, Guangmei Olson, Ken
source	Medline; PMC
abstract	Long intergenic non-coding RNAs (lincRNAs) are appearing as an important class of regulatory RNAs with a variety of biological functions. The aim of this study was to identify the lincRNA profile in the dengue vector Aedes aegypti and evaluate their potential role in host-pathogen interaction. The majority of previous RNA-Seq transcriptome studies in Ae. aegypti have focused on the expression pattern of annotated protein coding genes under different biological conditions. Here, we used 35 publically available RNA-Seq datasets with relatively high depth to screen the Ae. aegypti genome for lincRNA discovery. This led to the identification of 3,482 putative lincRNAs. These lincRNA genes displayed a slightly lower GC content and shorter transcript lengths compared to protein-encoding genes. Ae. aegypti lincRNAs also demonstrate low evolutionary sequence conservation even among closely related species such as Culex quinquefasciatus and Anopheles gambiae. We examined their expression in dengue virus serotype 2 (DENV-2) and Wolbachia infected and non-infected adult mosquitoes and Aa20 cells. The results revealed that DENV-2 infection increased the abundance of a number of host lincRNAs, from which some suppress viral replication in mosquito cells. RNAi-mediated silencing of lincRNA_1317 led to enhancement in viral replication, which possibly indicates its potential involvement in the host anti-viral defense. A number of lincRNAs were also differentially expressed in Wolbachia-infected mosquitoes. The results will facilitate future studies to unravel the function of lncRNAs in insects and may prove to be beneficial in developing new ways to control vectors or inhibit replication of viruses in them.
has issue date	2016-10-19(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0005069
bibo:pmid	27760142
has license	cc-by
sha1sum (hex)	c25889c8a5469237f3437394d9c595f9af0c7c4c
schema:url	https://doi.org/10.1371/journal.pntd.0005069
resource representing a document's title	Identification of Aedes aegypti Long Intergenic Non-coding RNAs and Their Association with Wolbachia and Dengue Virus Infection
has PubMed Central identifier	PMC5070814
has PubMed identifier	27760142
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:c25889c8a5469237f3437394d9c595f9af0c7c4c#body_text
is schema:about of	covid:arg/c25889c8a5469237f3437394d9c595f9af0c7c4c named entity 'regulatory RNAs' named entity 'Aedes aegypti' named entity 'RNA-Seq' named entity 'lncRNAs' named entity 'DENV' named entity 'anti-viral' named entity 'viral replication' named entity 'lincRNA' named entity 'Wolbachia' named entity 'transcriptome' named entity 'mosquitoes' named entity 'sequence conservation' named entity 'lincRNA' named entity 'non-coding RNAs' named entity 'replication of viruses' named entity 'lincRNAs' named entity 'viral replication' named entity 'Non-coding RNAs' named entity 'Anopheles' named entity 'biological processes' named entity 'mRNA' named entity 'genome' named entity 'Kbp' named entity 'lncRNA' named entity 'RNA' named entity 'lncRNAs' named entity 'microbial' named entity 'repetitive elements' named entity 'genome' named entity 'severe acute respiratory syndrome coronavirus' named entity 'Ae. aegypti' named entity 'lincRNAs' named entity 'dengue virus serotype 2' named entity 'pathogens' named entity 'differentially expressed' named entity '0.01' named entity 'RNA-Seq' named entity 'genomic imprinting' named entity 'ORF' named entity 'endogenous' named entity 'Ae. aegypti' named entity 'lincRNAs' named entity 'Culex quinquefasciatus' named entity 'Ae. aegypti' named entity 'viruses' named entity 'Wolbachia' named entity 'hybridization' named entity 'small RNA' named entity 'Ae. aegypti' named entity 'lncRNAs' named entity 'lincRNAs' named entity 'lincRNA' named entity 'RNA' named entity 'anti-viral' named entity 'NEAT1' named entity 'long ncRNA' named entity 'virus replication' named entity 'expression profile' named entity 'lncRNA' named entity 'Ae. aegypti' named entity 'minimum free energy' named entity 'infection' named entity 'lincRNAs' named entity 'lincRNAs' named entity 'lincRNAs' named entity 'transfection' named entity 'DENV' named entity 'lung' named entity 'transcriptional' named entity 'DENV' named entity 'mosquitoes' named entity 'base-pairing' named entity 'Wolbachia' named entity 'protein coding genes' named entity 'lincRNAs' named entity 'mosquito' named entity 'non-coding'

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