About: Coronavirus Immunoreactivity in Individuals With a Recent Onset of Psychotic Symptoms

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About: Coronavirus Immunoreactivity in Individuals With a Recent Onset of Psychotic Symptoms Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coronavirus Immunoreactivity in Individuals With a Recent Onset of Psychotic Symptoms
Creator	Dickerson, Faith Yolken, Robert Severance, Emily Viscidi, Raphael Bossis, Ioannis Sullens, Anne Origoni, Andrea Stallings, Cassie
Source	Medline; PMC
abstract	Prenatal influenza exposure increases the risk for schizophrenia and brings to question how other respiratory viruses may contribute to neuropsychiatric disease etiopathology. Human coronaviruses cause respiratory infections that range in seriousness from common colds to severe acute respiratory syndrome. Like influenza, coronaviruses can be neurotropic. To test for associations between coronaviruses and serious mental disorders, we utilized a recently developed assay and measured immunoglobulin G (IgG) response against 4 human coronavirus strains (229E, HKU1, NL63, and OC43) in 106 patients with a recent onset of psychotic symptoms and 196 nonpsychiatric controls. We expressed results quantitatively as antibody levels and qualitatively as seroprevalence relative to a defined seropositivity cutoff value. Patient IgG levels were higher than controls for HKU1, NL63, and OC43, with HKU1 and NL63 both showing highly significant patient-to-control differences (HKU1, P ≤ .002; NL63, P ≤ .00001). All 4 coronaviruses were more seroprevalent in patients vs controls, with greatest intergroup differences observed for HKU1 (93% vs 77%, P ≤ .0001). HKU1 and NL63 associations with the patient group were further supported by multivariate analyses that controlled for age, gender, race, socioeconomic status, and smoking status (HKU1, odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.03–1.67, P ≤ .027; NL63, OR = 2.42, 95% CI = 1.25–4.66, P ≤ .008). Among patients, NL63 was associated with schizophrenia-spectrum (OR = 3.10, 95% CI = 1.27–7.58, P ≤ .013) but not mood disorders. HKU1 and NL63 coronavirus exposures may represent comorbid risk factors in neuropsychiatric disease. Future studies should explore links between the timing of coronavirus infections and subsequent development of schizophrenia and other disorders with psychotic symptoms.
has issue date	2009-06-02(xsd:dateTime)
bibo:doi	10.1093/schbul/sbp052
bibo:pmid	19491313
has license	bronze-oa
sha1sum (hex)	c2314715d445b896f1c0e4b00636a6bdbbf2daf0
schema:url	https://doi.org/10.1093/schbul/sbp052
resource representing a document's title	Coronavirus Immunoreactivity in Individuals With a Recent Onset of Psychotic Symptoms
has PubMed Central identifier	PMC3004184
has PubMed identifier	19491313
schema:publication	Schizophrenia Bulletin
resource representing a document's body	covid:c2314715d445b896f1c0e4b00636a6bdbbf2daf0#body_text
is schema:about of	named entity 'CORONAVIRUS' named entity 'respiratory' named entity 'All 4' named entity 'qualitatively' named entity 'Human' named entity 'coronaviruses' named entity 'CONTROLLED' named entity 'RESPONSE' named entity 'NL63' named entity 'INDIVIDUALS' named entity 'LIKE' named entity 'INFLUENZA' named entity 'AGE' named entity 'RECENTLY' named entity 'PRENATAL' named entity 'EXPRESSED' named entity 'DISORDERS' named entity 'INCREASES' named entity 'RANGE' named entity 'SMOKING STATUS' named entity 'DEVELOPMENT' named entity 'SUBSEQUENT' named entity 'SPECTRUM' named entity 'NEUROTROPIC' named entity 'OBSERVED' named entity 'MEASURED' named entity 'CONTROL' named entity 'RACE' named entity 'BUT' named entity 'TO TEST' named entity 'LEVELS' named entity 'SEROPOSITIVITY' named entity 'IGG' named entity 'ASSOCIATIONS' named entity 'CORONAVIRUSES' named entity 'CONTRIBUTE ' named entity 'RESPIRATORY VIRUSES' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'DISEASE' named entity 'IMMUNOGLOBULIN G' named entity 'MENTAL DISORDERS' named entity 'SCHIZOPHRENIA' named entity 'COMORBID' named entity 'ASSOCIATED WITH' named entity 'STUDIES' named entity 'HUMAN' named entity 'VALUE' named entity 'PSYCHOTIC SYMPTOMS' named entity 'ONSET OF' named entity 'IMMUNOREACTIVITY' named entity '10%' named entity 'SEROPREVALENCE' named entity 'PATIENTS' named entity 'GREATEST' named entity 'EXPOSURES' named entity 'HIGHER' named entity 'CORONAVIRUS' named entity 'RECENT' named entity 'ODDS RATIO' named entity 'ANTIBODY' named entity 'DEFINED' named entity 'LINKS' named entity 'PSYCHOTIC SYMPTOMS' named entity 'NEUROPSYCHIATRIC' named entity 'SUPPORTED' named entity 'RISK FACTORS' named entity 'FUTURE' named entity 'SOCIOECONOMIC STATUS' named entity 'TO QUESTION' named entity 'RECENT' named entity 'ASSAY' named entity 'MOOD DISORDERS' named entity 'HUMAN CORONAVIRUS' named entity '008'

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