About: Identification of G-quadruplex forming sequences in three manatee papillomaviruses

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About: Identification of G-quadruplex forming sequences in three manatee papillomaviruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of G-quadruplex forming sequences in three manatee papillomaviruses
Creator	Joh, Joongho Khanal, Sujita Zahin, Maryam Chariker, Julia Rico, Puerto Rouchka, Eric Bossart, Gregory Chaires, Jonathan Dean, William Ghim, Shin-Je Graham, James Gray, Robert Jenson, Alfred Mignucci-Giannoni, Antonio Trent, John
Source	Medline; PMC
abstract	The Florida manatee (Trichechus manatus latirotris) is a threatened aquatic mammal in United States coastal waters. Over the past decade, the appearance of papillomavirus-induced lesions and viral papillomatosis in manatees has been a concern for those involved in the management and rehabilitation of this species. To date, three manatee papillomaviruses (TmPVs) have been identified in Florida manatees, one forming cutaneous lesions (TmPV1) and two forming genital lesions (TmPV3 and TmPV4). We identified DNA sequences with the potential to form G-quadruplex structures (G4) across the three genomes. G4 were located on both DNA strands and across coding and non-coding regions on all TmPVs, offering multiple targets for viral control. Although G4 have been identified in several viral genomes, including human PVs, most research has focused on canonical structures comprised of three G-tetrads. In contrast, the vast majority of sequences we identified would allow the formation of non-canonical structures with only two G-tetrads. Our biophysical analysis confirmed the formation of G4 with parallel topology in three such sequences from the E2 region. Two of the structures appear comprised of multiple stacked two G-tetrad structures, perhaps serving to increase structural stability. Computational analysis demonstrated enrichment of G4 sequences on all TmPVs on the reverse strand in the E2/E4 region and on both strands in the L2 region. Several G4 sequences occurred at similar regional locations on all PVs, most notably on the reverse strand in the E2 region. In other cases, G4 were identified at similar regional locations only on PVs forming genital lesions. On all TmPVs, G4 sequences were located in the non-coding region near putative E2 binding sites. Together, these findings suggest that G4 are possible regulatory elements in TmPVs.
has issue date	2018-04-09(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0195625
bibo:pmid	29630682
has license	cc-by
sha1sum (hex)	c21f187377f454dff39c726a947077a5c74ae016
schema:url	https://doi.org/10.1371/journal.pone.0195625
resource representing a document's title	Identification of G-quadruplex forming sequences in three manatee papillomaviruses
has PubMed Central identifier	PMC5891072
has PubMed identifier	29630682
schema:publication	PLoS One
resource representing a document's body	covid:c21f187377f454dff39c726a947077a5c74ae016#body_text
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