About: Dynamics of peripheral immune cells and their HLA‐G and receptor expressions in a patient suffering from critical COVID‐19 pneumonia to convalescence

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About: Dynamics of peripheral immune cells and their HLA‐G and receptor expressions in a patient suffering from critical COVID‐19 pneumonia to convalescence Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dynamics of peripheral immune cells and their HLA‐G and receptor expressions in a patient suffering from critical COVID‐19 pneumonia to convalescence
Creator	Zhang, Sheng Zheng, Dan Chen, Bao-Guo Gan, Jun Lin, Aifen Lin, Rong-Hai Yan, Wei-Hua Yang, Wei-Ying Zhang, Jian-Gang Zhou, Yi-Ping
Source	Medline; PMC
abstract	OBJECTIVES: Host immune responses are indispensable to combat the disease. We report the dynamics of peripheral immune cells, cytokines, and human leucocyte antigen‐G (HLA‐G) and its receptor expressions in a patient suffering from critical COVID‐19 pneumonia to convalescence. METHODS: Clinical data of the patient were collected from medical records. The expressions of HLA‐G and receptors ILT2, ILT4 and KIR2DL4 in peripheral immune cells were measured with flow cytometry. RESULTS: From critical COVID‐19 to the convalescent stage, early lymphopenia was improved (median: 0.6 × 10(9) L(−1) vs. 0.9 × 10(9) L(−1), P = 0.009), and an obvious fluctuation in WBC and neutrophil counts was observed. Initially, low levels of CD4(+) T cells (from 120 to 528 μL(−1)) and CD8(+) T cells (from 68 to 362 μL(−1)) gradually increased to normal levels. Meanwhile, high IL‐6 (from 251.8 to 6.32 pg mL(−1)), IL‐10 (from 39.53 to 5.21 pg mL(−1)) and IFN‐γ (from 13.55 to 3.16 pg mL(−1)) levels decreased, and IL‐4 (from 2.36 to 3.19 pg mL(−1)) and TNF‐α (from 2.27 to 20.2 pg mL(−1)) levels increased quickly when the viral RNA returned negative. Moreover, the percentage of HLA‐G(+) T cells, B cells and monocytes follows high–low–high pattern, while the percentage of receptors ILT2‐, ILT4‐ and KIR2DL4‐expressing cells remained relatively stable. CONCLUSION: Our findings provide valuable information on the dynamics of early peripheral immunological responses in SARS‐CoV‐2 infection. CD4(+) and CD8(+) T cells, cytokines and HLA‐G(+) immune cells are associated with the natural history of the critical COVID‐19 patient; however, future studies are necessary.
has issue date	2020-05-10(xsd:dateTime)
bibo:doi	10.1002/cti2.1128
bibo:pmid	32399213
has license	cc-by
sha1sum (hex)	c1ff49fbde89cf3e33a0e7d90e7f3692f60db71d
schema:url	https://doi.org/10.1002/cti2.1128
resource representing a document's title	Dynamics of peripheral immune cells and their HLA‐G and receptor expressions in a patient suffering from critical COVID‐19 pneumonia to convalescence
has PubMed Central identifier	PMC7211507
has PubMed identifier	32399213
schema:publication	Clin Transl Immunology
resource representing a document's body	covid:c1ff49fbde89cf3e33a0e7d90e7f3692f60db71d#body_text
is schema:about of	named entity 'cytokines' named entity 'T cells' named entity 'gradually' named entity 'levels' named entity 'HLA-G' named entity 'OBSERVED' named entity 'IMMUNE CELLS' named entity 'HOST' named entity 'T CELLS' named entity '251' named entity 'IL-4' named entity 'CLINICAL DATA' named entity 'RECEPTORS' named entity 'COVID-19 PNEUMONIA' named entity 'MONOCYTES' named entity 'LEVELS' named entity 'FLOW CYTOMETRY' named entity 'OBJECTIVES' named entity 'NEGATIVE' named entity 'HUMAN LEUCOCYTE ANTIGEN' named entity 'improved' named entity 'observed' named entity 'HLA-G' named entity 'IL-4' named entity 'human' named entity 'data' named entity 'Conclusion' named entity 'SARS-CoV-2' named entity 'patient' named entity 'patient' named entity 'peripheral' named entity 'CD8' named entity 'HLA-G' named entity 'viral' named entity 'monocytes' named entity 'CD8 +' named entity 'COVID' named entity 'IL-6' named entity 'immunological responses' named entity 'WBC' named entity 'ILT2' named entity 'immune cells' named entity 'infection' named entity 'TNF-a' named entity 'Host immune responses' named entity 'convalescence' named entity 'monocytes' named entity 'HLA-G' named entity 'immune cells' named entity 'ILT4' named entity 'cytokines' named entity 'IL-2' named entity 'chemokines' named entity 'RNA' named entity 'antigen presentation' named entity 'cytokine' named entity 'immune cell' named entity 'written consent' named entity 'SARS-CoV-2' named entity 'TNF-a' named entity 'infection' named entity 'SARS-CoV' named entity 'CD4 +' named entity 'H7N9' named entity 'COVID' named entity 'ILT2' named entity 'immune cells' named entity 'lymphocyte count' named entity 'MERS-CoV' named entity 'CD8 +' named entity 'TNF-a' named entity 'HLA'

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