About: Psoralen Inactivation of Viruses: A Process for the Safe Manipulation of Viral Antigen and Nucleic Acid

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About: Psoralen Inactivation of Viruses: A Process for the Safe Manipulation of Viral Antigen and Nucleic Acid Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Psoralen Inactivation of Viruses: A Process for the Safe Manipulation of Viral Antigen and Nucleic Acid
Creator	Burans, James Kochel, Tadeusz Leggett-Embrey, Melissa Ondov, Brian Schneider, Katherine Sun, Peifang Walker, Eric Wronka-Edwards, Loni Bohn, Sherry Rosovitz, M Wyman, Travis
Source	Medline; PMC
abstract	High consequence human pathogenic viruses must be handled at biosafety level 2, 3 or 4 and must be rendered non-infectious before they can be utilized for molecular or immunological applications at lower biosafety levels. Here we evaluate psoralen-inactivated Arena-, Bunya-, Corona-, Filo-, Flavi- and Orthomyxoviruses for their suitability as antigen in immunological processes and as template for reverse transcription PCR and sequencing. The method of virus inactivation using a psoralen molecule appears to have broad applicability to RNA viruses and to leave both the particle and RNA of the treated virus intact, while rendering the virus non-infectious.
has issue date	2015-11-12(xsd:dateTime)
bibo:doi	10.3390/v7112912
bibo:pmid	26569291
has license	cc-by
sha1sum (hex)	c1eb7483446895edd38acb64e683bfd905d54211
schema:url	https://doi.org/10.3390/v7112912
resource representing a document's title	Psoralen Inactivation of Viruses: A Process for the Safe Manipulation of Viral Antigen and Nucleic Acid
has PubMed Central identifier	PMC4664985
has PubMed identifier	26569291
schema:publication	Viruses
resource representing a document's body	covid:c1eb7483446895edd38acb64e683bfd905d54211#body_text
is schema:about of	named entity 'Arena' named entity 'biosafety' named entity 'molecule' named entity 'levels' named entity 'Viruses' covid:arg/c1eb7483446895edd38acb64e683bfd905d54211 named entity 'RNA' named entity 'sequencing' named entity 'virus' named entity 'virus' named entity 'non-infectious' named entity 'RNA viruses' named entity 'primary antibody' named entity 'UV-A' named entity 'real time PCR' named entity 'psoralen' named entity 'milliliter' named entity 'photoadducts' named entity 'fetal bovine serum' named entity 'IgG1 isotype' named entity '2.0' named entity 'Illumina' named entity 'psoralen' named entity 'reverse transcription PCR' named entity 'filtration' named entity 'base pairs' named entity 'Ebola' named entity 'microliters' named entity 'antibodies' named entity 'polyclonal antibodies' named entity 'cell culture' named entity 'host cells' named entity 'immunofluorescence' named entity 'UV-A' named entity 'UV-A light' named entity 'viruses' named entity 'UV-A' named entity 'biocontainment' named entity 'Rod-shaped' named entity 'dose-dependent' named entity 'Rift Valley Fever' named entity 'room temperature' named entity 'cell culture' named entity 'FACS' named entity 'host cells' named entity 'broth' named entity 'amplicon' named entity 'psoralen' named entity 'protein complexes' named entity 'DC-SIGN' named entity 'IgG antibody' named entity 'viruses' named entity 'molecule' named entity 'supernatants' named entity 'MERS-CoV' named entity 'thiocyanate' named entity 'acetone' named entity 'Applied Biosystems' named entity 'viruses' named entity 'real time PCR' named entity 'sterility' named entity 'energy level' named entity 'positive-sense RNA genome' named entity 'staining' named entity 'DENV' named entity 'UV-A' named entity 'Flow cytometry' named entity 'epitopes' named entity 'similar manner' named entity 'Antibodies' named entity 'fluorescent'

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