About: Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections

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About: Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections
Creator	Serban, Georgeta
Source	Medline; PMC
abstract	Viral infections have resulted in millions of victims in human history. Although great efforts have been made to find effective medication, there are still no drugs that truly cure viral infections. There are currently approximately 90 drugs approved for the treatment of human viral infections. As resistance toward available antiviral drugs has become a global threat to health, there is an intrinsic need to identify new scaffolds that are useful in discovering innovative, less toxic and highly active antiviral agents. 1,3,4-Thiadiazole derivatives have been extensively studied due to their pharmacological profile, physicochemical and pharmacokinetic properties. This review provides an overview of the various synthetic compounds containing the 2-amino-1,3,4-thiadiazole moiety that has been evaluated for antiviral activity against several viral strains and could be considered possible prototypes for the development of new antiviral drugs.
has issue date	2020-02-19(xsd:dateTime)
bibo:doi	10.3390/molecules25040942
bibo:pmid	32093125
has license	cc-by
sha1sum (hex)	c19f426a9602e64794abc621c69358c119448fbc
schema:url	https://doi.org/10.3390/molecules25040942
resource representing a document's title	Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections
has PubMed Central identifier	PMC7070519
has PubMed identifier	32093125
schema:publication	Molecules
resource representing a document's body	covid:c19f426a9602e64794abc621c69358c119448fbc#body_text
is schema:about of	named entity 'strains' named entity 'human' named entity 'profile' named entity 'synthetic' named entity 'Thiadiazole' named entity 'VIRAL INFECTIONS' named entity 'PROPERTIES' named entity 'STRAINS' named entity 'PROFILE' named entity 'THIADIAZOLE' named entity 'ANTIVIRAL AGENTS' named entity 'CURE' named entity 'PROTOTYPES' named entity 'VIRAL' named entity 'RESISTANCE' named entity 'APPROXIMATELY' named entity 'TOXIC' named entity 'HISTORY' named entity 'NEED' named entity 'MOIETY' named entity 'THEIR' named entity 'DRUGS' named entity 'PHARMACOKINETIC' named entity 'REVIEW' named entity 'SCAFFOLDS' named entity 'POSSIBLE' named entity 'HAVE' named entity 'MOIETY' named entity '2C4' named entity 'SYNTHETIC' named entity 'VARIOUS' named entity 'VIRAL INFECTIONS' named entity 'TREATMENT' named entity 'HEALTH' named entity 'DEVELOPMENT' named entity 'DUE TO' named entity 'CONSIDERED' named entity 'PHARMACOLOGICAL' named entity 'AMINO' named entity 'PROVIDES' named entity 'THIADIAZOLE' named entity 'MOLECULES' named entity 'TO IDENTIFY' named entity 'USEFUL' named entity 'COULD BE' named entity '2C4' named entity 'GREAT' named entity 'CONTAINING' named entity 'HUMAN' named entity 'HIGHLY' named entity 'EFFECTIVE' named entity 'GLOBAL' named entity 'ANTIVIRAL ACTIVITY' named entity 'AMINO' named entity 'ANTIVIRAL DRUGS' named entity 'VICTIMS' named entity 'APPROVED' named entity 'SYNTHETIC' named entity 'MEDICATION' named entity 'NEW' named entity 'OVERVIEW' named entity 'PHYSICOCHEMICAL' named entity 'CURRENTLY' named entity 'ACTIVE' named entity 'AVAILABLE' named entity 'EVALUATED' named entity 'INTRINSIC' named entity 'THREAT' covid:arg/c19f426a9602e64794abc621c69358c119448fbc named entity 'Viral infections' named entity 'Although' named entity 'moiety' named entity 'health' named entity 'thiadiazole' named entity 'antiviral drugs' named entity 'scaffolds' named entity 'antiviral drugs' named entity 'antiviral agents' named entity 'moiety' named entity 'human history' named entity 'potency'

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