About: Flagellin from Pseudomonas aeruginosa increases the expression of the SARS-CoV2 entry protease TMPRSS2 in airway epithelial cells

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About: Flagellin from Pseudomonas aeruginosa increases the expression of the SARS-CoV2 entry protease TMPRSS2 in airway epithelial cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Flagellin from Pseudomonas aeruginosa increases the expression of the SARS-CoV2 entry protease TMPRSS2 in airway epithelial cells
Creator	Balloy, Viviane Corvol, Harriet Guillot, Loïc Bigot, Jeanne Calmel, Claire Ruffin, Manon
Source	BioRxiv
abstract	The major challenge of the COVID-19 health crisis is to identify the factors of susceptibility to SARS-Cov2 in order to adapt the recommendations to the populations and to reduce the risk of getting COVID-19 to the most vulnerable people especially those having chronic respiratory diseases (CRD) including cystic fibrosis (CF) and chronic pulmonary respiratory diseases (COPD). Airway epithelial cells (AEC) are playing a critical role in the immune response and in COVID-19 severity. SARS-CoV-2 infects the airways through ACE2 receptor and the host protease TMPRSS2 was shown to play a major role in SARS-CoV-2 infectivity. In this report we showed that Pseudomonas aeruginosa and its virulence factor flagellin (Fla-PA), a ligand of Toll-Like receptor 5 are able to increase TMPRSS2 expression in control and CF AEC. In contrast, no effect was observed with recombinant Salmonella typhimurium flagellin, used as an adjuvant in the clinical development of new vaccines against respiratory viruses. Considering the urgency of the health situation, this result is of major significance for patients with CRD (COPD, CF) which are frequently infected and colonized by P. aeruginosa during the course of the disease. In the general population, a P. aeruginosa ventilator-associated pneumonia in SARS-CoV-2 patients under intubation in intensive care units could be also deleterious and should be monitored with care.
has issue date	2020-08-24(xsd:dateTime)
bibo:doi	10.1101/2020.08.24.264564
has license	biorxiv
sha1sum (hex)	c1881582f039c87546bb56e908a3fa71507295b1
schema:url	https://doi.org/10.1101/2020.08.24.264564
resource representing a document's title	Flagellin from Pseudomonas aeruginosa increases the expression of the SARS-CoV2 entry protease TMPRSS2 in airway epithelial cells
schema:publication	bioRxiv
resource representing a document's body	covid:c1881582f039c87546bb56e908a3fa71507295b1#body_text
is schema:about of	named entity 'adapt' named entity 'Airway' named entity 'protease' named entity 'risk' named entity 'COVID-19' named entity 'protease' named entity 'A MAJOR' named entity 'COPD' named entity 'critical role' named entity 'reduce' named entity 'chronic' named entity 'order' named entity 'host' named entity 'TMPRSS2' named entity 'epithelial cells' named entity 'cystic fibrosis' named entity 'Airway' named entity 'ACE2 receptor' named entity 'SARS' named entity 'immune response' named entity 'CRD' named entity 'SARS-CoV2' named entity 'factors' named entity 'viruses' named entity 'SARS-CoV-2' named entity 'asthma' named entity 'intensive care units' named entity 'cystic fibrosis' named entity 'follow-up' named entity 'pathogens' named entity 'miRNA' named entity 'infection' named entity 'primary antibodies' named entity 'IL-8' named entity 'chronic respiratory diseases' named entity 'CRD' named entity 'bioimaging' named entity 'qPCR' named entity 'ACE2' named entity 'Coronavirus' named entity 'flagellin' named entity 'statistical significance' named entity 'intubation' named entity 'SARS-CoV-2' named entity 'CoV' named entity 'TMPRSS2' named entity 'Airway' named entity 'immune response' named entity 'flagellin' named entity 'Flagellin' named entity 'ligand' named entity 'SARS-CoV-2' named entity 'P. aeruginosa' named entity 'basic research' named entity 'TMPRSS2' named entity 'Fluorescence microscopy' named entity 'epithelial cells' named entity 'adjuvant' named entity 'TMPRSS2' named entity 'flagellin' named entity 'inflammatory response' named entity 'FURIN' named entity 'GAPDH' named entity 'PBS' named entity 'Cell signaling technology' named entity 'Germany' named entity 'SARS-CoV-2' named entity 'lung' named entity 'SARS-CoV-2' named entity 'Biorad' named entity 'COPD' named entity 'TMPRSS2' named entity 'virulence factor' named entity 'flagellin' named entity 'F508del' named entity 'Influenza' named entity 'Calu-3' named entity 'recombinant' named entity 'CFTR'

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