About: Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization
Creator	Chevet, Eric Lafont, Frank Bernard, Sandra Bourdoulous, Sandrine Bouzinba-Ségard, Haniaa Chretien, Fabrice Couraud, Pierre-Olivier Coureuil, Mathieu Federici, Christian Janel, Sébastien Join-Lambert, Olivier Laran-Chich, Marie-Pierre Marullo, Stefano Maïssa, Nawal Morand, Philippe Nassif, Xavier Niedergang, Florence Segura, Audrey Simpson, Nandi Taouji, Saïd
source	Medline; PMC
abstract	Neisseria meningitidis is a cause of meningitis epidemics worldwide and of rapidly progressing fatal septic shock. A crucial step in the pathogenesis of invasive meningococcal infections is the adhesion of bloodborne meningococci to both peripheral and brain endothelia, leading to major vascular dysfunction. Initial adhesion of pathogenic strains to endothelial cells relies on meningococcal type IV pili, but the endothelial receptor for bacterial adhesion remains unknown. Here, we report that the immunoglobulin superfamily member CD147 (also called extracellular matrix metalloproteinase inducer (EMMPRIN) or Basigin) is a critical host receptor for the meningococcal pilus components PilE and PilV. Interfering with this interaction potently inhibited the primary attachment of meningococci to human endothelial cells in vitro and prevented colonization of vessels in human brain tissue explants ex vivo and in humanized mice in vivo. These findings establish the molecular events by which meningococci target human endothelia, and they open new perspectives for treatment and prevention of meningococcus-induced vascular dysfunctions. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nm.3563) contains supplementary material, which is available to authorized users.
has issue date	2014-06-01(xsd:dateTime)
bibo:doi	10.1038/nm.3563
bibo:pmid	24880614
has license	no-cc
sha1sum (hex)	c1490290ea9d778e4ab19627eaa3ccce3d696368
schema:url	https://doi.org/10.1038/nm.3563
resource representing a document's title	Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization
has PubMed Central identifier	PMC7095922
has PubMed identifier	24880614
schema:publication	Nat Med
resource representing a document's body	covid:c1490290ea9d778e4ab19627eaa3ccce3d696368#body_text
is schema:about of	named entity 'molecular' named entity 'epidemics' named entity 'adhesion' named entity 'meningococcal infections' named entity 'prevented' named entity 'vascular' named entity 'meningococci' named entity 'perspectives' named entity 'colonization' covid:arg/c1490290ea9d778e4ab19627eaa3ccce3d696368 named entity 'peripheral' named entity 'explants' named entity 'prevention' named entity 'endothelia' named entity 'inhibited' named entity 'extracellular matrix' named entity 'endothelial cells' named entity 'brain tissue' named entity 'colonization' named entity 'vivo' named entity 'Pathogenic' named entity 'endothelial cells' named entity 'receptor' named entity 'humanized mice' named entity 'meningococci' named entity 'epidemics' named entity 'meningococci' named entity 'bacterial adhesion' named entity 'endothelial receptor' named entity 'receptor' named entity 'locus' named entity 'meningococcal' named entity 'infection' named entity 'human skin' named entity 'human brain' named entity 'meningococcus' named entity 'purpura fulminans' named entity 'endothelial cells' named entity 'antimicrobial therapy' named entity 'protein' named entity 'epidermal growth factor' named entity 'endothelial cell' named entity 'evolutionarily conserved' named entity 'lysed' named entity 'pathogen' named entity 'post-translational modifications' named entity 'malaria' named entity 'endothelial' named entity 'constitutively expressed' named entity 'epithelial' named entity 'frontal brain' named entity 'IPTG' named entity 'binding site' named entity 'meningococcal' named entity 'cell-cell junctions' named entity 'CD147' named entity 'endothelial dysfunction' named entity 'bacteria' named entity 'bacterial pathogen' named entity 'ICAM-1' named entity 'Ig domain' named entity 'statistical analysis'

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