About: Proteomic analysis revealed T cell hyporesponsiveness induced by Haemonchus contortus excretory and secretory proteins

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About: Proteomic analysis revealed T cell hyporesponsiveness induced by Haemonchus contortus excretory and secretory proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Proteomic analysis revealed T cell hyporesponsiveness induced by Haemonchus contortus excretory and secretory proteins
Creator	Li, Xiangrui Yang, Zhang Li, Charles Lu, Mingmin Song, Xiaokai Tian, Ai-Ling Tian, Xiaowei Wang, Wenjuan Xu, Lixin Yan, Ruofeng
Source	PMC
abstract	Haemonchus contortus has evolved highly integrated and sophisticated mechanisms to promote coexistence with hosts. The excretory-secretory (ES) products generated by this parasite contribute to the regulation of the host immune response to facilitate immune evasion and induce chronicity, but the proteins responsible for this process and the exact cellular mechanisms have yet to be defined. In this study, we identified 114 H. contortus ES proteins (HcESPs) interacting with host T cells and 15 T cell binding receptors via co-immunoprecipitation and shotgun liquid chromatography-tandem mass spectrometry analysis. Based on bioinformatics analysis, we demonstrated that HcESPs could inhibit T cell viability, induce cell apoptosis, suppress T cell proliferation and cause cell cycle arrest. Furthermore, the stimulation of HcESPs exerted critical control effects on T cell cytokine production profiles, predominantly promoting the secretion of interleukin (IL)-10, IL-17A and transforming growth factor-β1 and inhibiting IL-2, IL-4 and interferon-γ production. Collectively, these findings may provide insights into the interaction between ES proteins and key host effector cells, enhancing our understanding of the molecular mechanism underlying parasite immune evasion and providing new clues for novel vaccine development.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.1186/s13567-020-00790-0
bibo:pmid	32404195
has license	cc-by
sha1sum (hex)	c0b9b9426c31014372750fb2818f5a1de6b1c6d4
schema:url	https://doi.org/10.1186/s13567-020-00790-0
resource representing a document's title	Proteomic analysis revealed T cell hyporesponsiveness induced by Haemonchus contortus excretory and secretory proteins
has PubMed Central identifier	PMC7222441
has PubMed identifier	32404195
schema:publication	Vet Res
resource representing a document's body	covid:c0b9b9426c31014372750fb2818f5a1de6b1c6d4#body_text
is schema:about of	named entity 'proteins' named entity 'cellular' named entity 'Haemonchus contortus' named entity 'process' named entity 'binding' named entity 'induce' named entity 'T cell' named entity 'Proteomic' named entity 'T CELL' named entity 'THESE' named entity 'VACCINE DEVELOPMENT' named entity 'STUDY' named entity 'HOSTS' named entity 'CAUSE' named entity 'HIGHLY' named entity 'FINDINGS' named entity 'B21' named entity 'MASS SPECTROMETRY ANALYSIS' named entity '10%' named entity 'SHOTGUN' named entity 'LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY' named entity 'CELL VIABILITY' named entity 'CONTROL' named entity 'IL-17A' named entity 'HOST' named entity 'INTERFERON' named entity 'IL-2' named entity 'induce' named entity 'receptors' named entity 'proteins' named entity 'identified' named entity 'stimulation' named entity 'H. contortus' named entity 'T cell' named entity 'mechanisms' named entity 'IL-2' named entity 'immune response' named entity 'Haemonchus contortus' named entity 'liquid chromatography-tandem mass spectrometry' named entity 'molecular mechanism' named entity 'bioinformatics' named entity 'interferon-γ' named entity 'transforming growth factor-β1' named entity 'vaccine' named entity 'excretory' named entity 'Haemonchus contortus' named entity 'G2/M' named entity 'Cell viability tests' named entity 'venom' named entity 'ethanol' named entity 'Acanthocheilonema viteae' named entity 'control group' named entity 'cytokine' named entity 'goat' named entity 'MACS' named entity 'TGF-β1' named entity 'autocatalysis' named entity 'Caspase-3' named entity 'biological process' named entity 'Apoptosis' named entity 'anthelmintic' named entity 'Necator americanus' named entity 'CDK6' named entity 'DAB' named entity 'Th1' named entity 'S-phase' named entity 'IL-2' named entity 'DR5' named entity 'Akt' named entity 'IL-4' named entity 'polyclonal antibody' named entity 'ion'

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