About: MDS disease characteristics, not donor source, predict hematopoietic stem cell transplant outcomes

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MDS disease characteristics, not donor source, predict hematopoietic stem cell transplant outcomes
Creator	Bejanyan, N Brunstein, C Dolan, M Pourhassan, H Trottier, B Ustun, C Warlick, E Defor, T
Source	PMC
abstract	Myelodysplastic syndrome (MDS) is a heterogeneous group of hematological malignancies with considerably variable prognoses and curable only with hematopoietic cell transplantation (HCT). Few studies comparing MDS HCT outcomes between sibling and umbilical cord blood (UCB) donors exist. Using the University of Minnesota Blood and Marrow Transplant (BMT) database, we retrospectively analyzed HCT outcomes among 89 MDS patients undergoing either sibling or double UCB HCT in 2000–2013. We observed similar survival, relapse and non-relapse mortality between sibling and UCB donor sources. Relapse was increased in those with monosomal karyotype (P=0.04) and with reduced intensity conditioning (P<0.01). In summary, our data highlight similar MDS HCT outcomes regardless of donor source and support the use of UCB as an alternative donor when a sibling is unavailable.
has issue date	2016-12-12(xsd:dateTime)
bibo:doi	10.1038/bmt.2016.303
bibo:pmid	27941767
has license	no-cc
sha1sum (hex)	c08db9a3bc3b52f6c3036f279e762f0bc713b772
schema:url	https://doi.org/10.1038/bmt.2016.303
resource representing a document's title	MDS disease characteristics, not donor source, predict hematopoietic stem cell transplant outcomes
has PubMed Central identifier	PMC5382091
has PubMed identifier	27941767
schema:publication	Bone Marrow Transplant
resource representing a document's body	covid:c08db9a3bc3b52f6c3036f279e762f0bc713b772#body_text
is schema:about of	named entity 'patients' named entity 'hematopoietic stem cell' named entity 'Marrow' named entity 'UCB' named entity 'UCB' named entity 'disease-free survival' named entity 'prognostic' named entity 'GVHD' named entity 'chi-square test' named entity 'ATG' named entity 'UCB' named entity 'MDS' named entity 'cytogenetic' named entity 'stem cell' named entity 'DFS' named entity 'supportive care' named entity 'DFS' named entity 'MUD' named entity 'multiple regression analysis' named entity 'Karnofsky' named entity 'retrospectively' named entity 'mortality' named entity 'Transplant' named entity 'disease burden' named entity '95% CI' named entity '95% CI' named entity 'multivariate analysis' named entity 'MDS' named entity 'RIC' named entity 'cytogenetic' named entity 'RIC' named entity 'relapse' named entity 'UCB' named entity '95% CI' named entity 'high-risk' named entity 'MDS' named entity 'MDS' named entity 'prophylaxis' named entity 'ATG' named entity 'UCB' named entity 'MDS' named entity 'allogeneic stem cell transplant' named entity 'HLA' named entity 'GVHD' named entity 'topoisomerase II' named entity 'RIC' named entity 'cytogenetics' named entity 'remission' named entity 'MDS' named entity 'AML' named entity 'serostatus' named entity 'University of Minnesota' named entity 'DRB1' named entity '95% CI' named entity 'myeloablative' named entity 'monosomies' named entity 'hematological malignancies' named entity 'conditioning' named entity 'comparing' named entity 'MDS' named entity 'MDS' named entity 'UCB' named entity 'University of Minnesota' named entity 'Marrow Transplant' named entity 'MDS' named entity 'hematological malignancies' named entity 'relapse' named entity 'umbilical cord blood' named entity 'hematopoietic stem cell transplant' named entity 'Myelodysplastic syndromes' named entity 'MDS' named entity 'hematopathologists' named entity 'umbilical cord blood' named entity 'GVHD'

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