About: Comparative genomics suggests limited variability and similar evolutionary patterns between major clades of SARS-CoV-2

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About: Comparative genomics suggests limited variability and similar evolutionary patterns between major clades of SARS-CoV-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparative genomics suggests limited variability and similar evolutionary patterns between major clades of SARS-CoV-2
Creator	Chiara, Matteo Gissi, Horner, David Pesole, Graziano
Source	BioRxiv
abstract	Phylogenomic analysis of SARS-CoV-2 as available from publicly available repositories suggests the presence of 3 prevalent groups of viral episomes (super-clades), which are mostly associated with outbreaks in distinct geographic locations (China, USA and Europe). While levels of genomic variability between SARS-CoV-2 isolates are limited, to our knowledge, it is not clear whether the observed patterns of variability in viral super-clades reflect ongoing adaptation of SARS-CoV-2, or merely genetic drift and founder effects. Here, we analyze more than 1100 complete, high quality SARS-CoV-2 genome sequences, and provide evidence for the absence of distinct evolutionary patterns/signatures in the genomes of the currently known major clades of SARS-CoV-2. Our analyses suggest that the presence of distinct viral episomes at different geographic locations are consistent with founder effects, coupled with the rapid spread of this novel virus. We observe that while cross species adaptation of the virus is associated with hypervariability of specific protein coding regions (including the RDB domain of the spike protein), the more variable genomic regions between extant SARS-CoV-2 episomes correspond with the 3’ and 5’ UTRs, suggesting that at present viral protein coding genes should not be subjected to different adaptive evolutionary pressures in different viral strains. Although this study can not be conclusive, we believe that the evidence presented here is strongly consistent with the notion that the biased geographic distribution of SARS-CoV-2 isolates should not be associated with adaptive evolution of this novel pathogen.
has issue date	2020-04-04(xsd:dateTime)
bibo:doi	10.1101/2020.03.30.016790
has license	biorxiv
sha1sum (hex)	c03fd1659e0b27091c1ff54f539072cfd167ed66
schema:url	https://doi.org/10.1101/2020.03.30.016790
resource representing a document's title	Comparative genomics suggests limited variability and similar evolutionary patterns between major clades of SARS-CoV-2
schema:publication	bioRxiv
resource representing a document's body	covid:c03fd1659e0b27091c1ff54f539072cfd167ed66#body_text
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