About: Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1

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About: Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1
Creator	Yoo, Dongwan Zhang, Qingzhan Shi, Kaichuang
Source	Elsevier; Medline; PMC
abstract	Abstract Type I interferons (IFN-α/β) are the major components of the innate immune response of hosts, and in turn many viruses have evolved to modulate the host response during infection. We found that the IFN-β production was significantly suppressed during PEDV infection in cells. To identify viral IFN antagonists and to study their suppressive function, viral coding sequences for the entire structural and nonstructural proteins were cloned and expressed. Of 16 PEDV nonstructural proteins (nsps), nsp1, nsp3, nsp7, nsp14, nsp15 and nsp16 were found to inhibit the IFN-β and IRF3 promoter activities. The sole accessory protein ORF3, structure protein envelope (E), membrane (M), and nucleocapsid (N) protein were also shown to inhibit such activities. PEDV nsp1 did not interfere the IRF3 phosphorylation and nuclear translocation but interrupted the enhanceosome assembly of IRF3 and CREB-binding protein (CBP) by degrading CBP. A further study showed that the CBP degradation by nsp1 was proteasome-dependent. Our data demonstrate that PEDV modulates the host innate immune responses by degrading CBP and suppressing ISGs expression.
has issue date	2016-02-29(xsd:dateTime)
bibo:doi	10.1016/j.virol.2015.12.010
bibo:pmid	26773386
has license	els-covid
sha1sum (hex)	bf38470c3511d73a2e7c8fe36772bec1d0f95f4a
schema:url	https://doi.org/10.1016/j.virol.2015.12.010
resource representing a document's title	Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1
has PubMed Central identifier	PMC7111358
has PubMed identifier	26773386
schema:publication	Virology
resource representing a document's body	covid:bf38470c3511d73a2e7c8fe36772bec1d0f95f4a#body_text
is schema:about of	named entity 'cloned' named entity 'modulates' named entity 'IFN-α' named entity 'demonstrate' named entity 'phosphorylation' named entity 'nucleocapsid' named entity 'CREB-BINDING PROTEIN' named entity 'THEIR' named entity 'EVOLVED' named entity 'MEMBRANE' named entity 'PHOSPHORYLATION' named entity 'IFN' named entity 'DEGRADATION' named entity 'HOST RESPONSE' named entity 'TYPE I INTERFERONS' named entity 'TO IDENTIFY' named entity 'BUT' named entity 'IRF3' named entity 'STRUCTURE' named entity 'VIRUSES' named entity 'ANTAGONISTS' named entity 'STRUCTURAL' named entity 'ENHANCEOSOME' named entity 'SUPPRESSION' named entity 'TYPE I INTERFERON PRODUCTION' named entity 'OUR' named entity 'CREB-BINDING PROTEIN' named entity 'NONSTRUCTURAL PROTEINS' named entity 'PROTEIN ' named entity 'NSP1' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'TO INHIBIT' named entity 'MAJOR' named entity 'DATA' named entity 'PEDV' named entity 'ACCESSORY PROTEIN' named entity 'INTERRUPTED' named entity 'ORF3' named entity 'IMMUNE RESPONSES' named entity 'ACTIVITIES' named entity 'ENVELOPE' named entity 'CLONED' named entity 'PRODUCTION' named entity 'SEQUENCES' named entity 'INFECTION' named entity 'MODULATE' named entity 'SOLE' named entity 'HOST' named entity 'CBP' named entity 'CELLS' named entity 'INNATE IMMUNE RESPONSE' named entity 'PROMOTER' named entity 'DID' named entity 'ENTIRE' named entity 'VIRAL' named entity 'INTERFERE' named entity 'SUPPRESSIVE' named entity 'NSP1' named entity 'NSP3' named entity 'EXPRESSED' named entity 'DEPENDENT' named entity 'NUCLEAR TRANSLOCATION' named entity 'TURN' named entity 'FOUND' named entity 'ASSEMBLY' named entity 'STUDY' named entity 'COMPONENTS' named entity 'CODING' named entity 'SUPPRESSED' named entity 'FUNCTION' named entity 'HOSTS' named entity 'PROTEIN ' named entity 'DEGRADATION' named entity 'EXPRESSION' named entity 'HAVE' named entity 'PROTEASOME' named entity 'NUCLEOCAPSID' covid:arg/bf38470c3511d73a2e7c8fe36772bec1d0f95f4a named entity 'NSP7'

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