About: Comprehensive analysis of drugs to treat SARS-CoV-2 infection: Mechanistic insights into current COVID-19 therapies (Review)

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About: Comprehensive analysis of drugs to treat SARS-CoV-2 infection: Mechanistic insights into current COVID-19 therapies (Review) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comprehensive analysis of drugs to treat SARS-CoV-2 infection: Mechanistic insights into current COVID-19 therapies (Review)
Creator	Moschos, Sterghios Nitulescu, George Spandidos, A Tsatsakis, Aristidis Drakoulis, Nikolaos Mihai Nitulescu, George Nicolae Daniel Ion, George Nikolouzakis, Taxiarchis Nitulescu, Georgiana Paunescu, Horia
Source	Medline; PMC; WHO
abstract	The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) focused many researchers attention to find treatments that can suppress transmission or ameliorate the disease. Despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID-19). This work represents an exhaustive and critical review of all available data on potential treatments for COVID-19, highlighting their mechanistic characteristics and the strategy development rationale. Drug repurposing, also known as drug repositioning, and target based methods are the most used strategies to advance therapeutic solutions into clinical practice. Current in silico, in vitro and in vivo evidence regarding proposed treatments are summarized providing strong support for future research efforts.
has issue date	2020-05-18(xsd:dateTime)
bibo:doi	10.3892/ijmm.2020.4608
bibo:pmid	32468014
has license	cc-by-nc-nd
sha1sum (hex)	bee57fc1cc574d9c8bb84da8af78789a75e32012
schema:url	https://doi.org/10.3892/ijmm.2020.4608
resource representing a document's title	Comprehensive analysis of drugs to treat SARS-CoV-2 infection: Mechanistic insights into current COVID-19 therapies (Review)
has PubMed Central identifier	PMC7307820
has PubMed identifier	32468014
schema:publication	Int J Mol Med
resource representing a document's body	covid:bee57fc1cc574d9c8bb84da8af78789a75e32012#body_text
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