About: Predicting virus emergence amid evolutionary noise

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Predicting virus emergence amid evolutionary noise
Creator	Holmes, Edward Geoghegan, Jemma
Source	Medline; PMC
abstract	The study of virus disease emergence, whether it can be predicted and how it might be prevented, has become a major research topic in biomedicine. Here we show that efforts to predict disease emergence commonly conflate fundamentally different evolutionary and epidemiological time scales, and are likely to fail because of the enormous number of unsampled viruses that could conceivably emerge in humans. Although we know much about the patterns and processes of virus evolution on evolutionary time scales as depicted in family-scale phylogenetic trees, these data have little predictive power to reveal the short-term microevolutionary processes that underpin cross-species transmission and emergence. Truly understanding disease emergence therefore requires a new mechanistic and integrated view of the factors that allow or prevent viruses spreading in novel hosts. We present such a view, suggesting that both ecological and genetic aspects of virus emergence can be placed within a simple population genetic framework, which in turn highlights the importance of host population size and density in determining whether emergence will be successful. Despite this framework, we conclude that a more practical solution to preventing and containing the successful emergence of new diseases entails ongoing virological surveillance at the human–animal interface and regions of ecological disturbance.
has issue date	2017-10-25(xsd:dateTime)
bibo:doi	10.1098/rsob.170189
bibo:pmid	29070612
has license	cc-by
sha1sum (hex)	bed1c9834dbd81a9e254940379f80c3447a122e9
schema:url	https://doi.org/10.1098/rsob.170189
resource representing a document's title	Predicting virus emergence amid evolutionary noise
has PubMed Central identifier	PMC5666085
has PubMed identifier	29070612
schema:publication	Open Biol
resource representing a document's body	covid:bed1c9834dbd81a9e254940379f80c3447a122e9#body_text
is schema:about of	named entity 'disease' named entity 'NOISE' named entity 'AMID' named entity 'EMERGENCE' named entity 'RESEARCH' named entity 'EMERGENCE' named entity 'VIRUS DISEASE' named entity 'BIOMEDICINE' named entity 'HOW' named entity 'A MAJOR' named entity 'MIGHT BE' named entity 'STUDY' named entity 'TOPIC' named entity 'PREDICTING' named entity 'VIRUS' named entity 'PREDICTED' named entity 'virus' named entity 'alleles' named entity 'RNA sequencing' named entity 'reservoir host' named entity 'predicted' named entity 'retroviruses' named entity 'biodiversity' named entity 'host species' named entity 'virus evolution' named entity 'evolutionary processes' named entity 'long-term' named entity 'AIDS' named entity 'population genetics' named entity 'epidemiological' named entity 'evolutionary theory' named entity 'fossils' named entity 'Saudi Arabia' named entity 'machine learning' named entity 'epidemic' named entity 'population genetic' named entity 'serological' named entity 'ecosystem' named entity 'phylogenies' named entity 'pathogen' named entity 'host adaptation' named entity 'biodiversity' named entity 'phylogenetic tree' named entity 'biodiversity' named entity 'bat' named entity 'phylogenetic' named entity 'macroevolution' named entity '2013-2016' named entity 'random sampling' named entity 'domestic dog' named entity 'cross-species transmission' named entity 'anthropogenic' named entity 'virus species' named entity 'experimental research' named entity 'metagenomics' named entity 'equine influenza virus' named entity 'epidemiological' named entity 'eukaryotes' named entity 'mutation' named entity 'fast rules' named entity 'anthropogenic' named entity 'cross-species transmission' named entity 'host species' named entity 'livestock' named entity 'evolutionary change' named entity 'biodiversity' named entity 'biodiversity' named entity 'population bottleneck' named entity 'animal reservoir' named entity 'allele' named entity 'genetic drift' named entity 'transmitted to humans' named entity 'virological' named entity 'ecological studies' named entity 'virus evolution' named entity 'epidemiology' named entity 'virus evolution' named entity 'vertebrate evolution' named entity 'population bottleneck' named entity 'eukaryotes'

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