About: What’s new in the renin-angiotensin system?: Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus

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About: What’s new in the renin-angiotensin system?: Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	What’s new in the renin-angiotensin system?: Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus
Creator	Choe, H Farzan, M Kuhn, J Li, W
Source	Medline; PMC
abstract	Cellular entry of enveloped viruses is often dependent on attachment proteins expressed on the host cell surface. Viral envelope proteins bind these receptors, and, in an incompletely understood process, facilitate fusion of the cellular and viral membranes so as to introduce the viral core into the cytoplasm. Only a small fraction of viral receptors have been identified so far. Recently, a novel coronavirus was identified as the etiological agent of severe acute respiratory syndrome (SARS). The fusion protein gene of SARS coronavirus (SARS-CoV) was cloned and characterized, and shortly thereafter, angiotensin-converting enzyme 2 (ACE2) was shown to be its functional receptor. Identification of ACE2 as a receptor for SARS-CoV will likely contribute to the development of antivirals and vaccines. It may also contribute to the development of additional animal models for studying SARS pathogenesis, and could help identify the animal reservoir of SARS-CoV.
has issue date	2004-01-01(xsd:dateTime)
bibo:doi	10.1007/s00018-004-4242-5
bibo:pmid	15549175
has license	no-cc
sha1sum (hex)	be9ea17af4cabeed0030ea421faf6e8542694cfd
schema:url	https://doi.org/10.1007/s00018-004-4242-5
resource representing a document's title	What’s new in the renin-angiotensin system?: Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus
has PubMed Central identifier	PMC7079798
has PubMed identifier	15549175
schema:publication	Cell Mol Life Sci
resource representing a document's body	covid:be9ea17af4cabeed0030ea421faf6e8542694cfd#body_text
is schema:about of	named entity 'FUNCTIONAL' named entity 'receptors' named entity 'Angiotensin-converting enzyme 2' named entity 'NOVEL CORONAVIRUS' named entity 'ENTRY' named entity 'BIND' named entity 'UNDERSTOOD' named entity 'VIRAL ENVELOPE PROTEINS' named entity 'CELLULAR' named entity 'MEMBRANES' covid:arg/be9ea17af4cabeed0030ea421faf6e8542694cfd named entity 'PROTEINS' named entity 'RECEPTOR' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'FRACTION OF' named entity 'FAR' named entity 'HAVE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'RECENTLY' named entity 'CYTOPLASM' named entity 'IDENTIFIED' named entity 'THESE' named entity 'VIRUSES' named entity 'VIRAL CORE' named entity 'SARS CORONAVIRUS' named entity 'HOST CELL SURFACE' named entity 'PRO-' named entity 'PROCESS' named entity 'SMALL' named entity 'RECEPTORS' named entity 'VIRAL' named entity 'FUSION' named entity 'ATTACHMENT' named entity 'EXPRESSED' named entity 'DEPENDENT' named entity 'INTRODUCE' named entity 'AGENT' named entity 'etiological agent' named entity 'proteins' named entity 'host' named entity 'cell' named entity 'receptors' named entity 'identified' named entity 'Viral envelope proteins' named entity 'viral core' named entity 'cytoplasm' named entity 'Angiotensin-converting enzyme 2' named entity 'amino acid sequence' named entity 'green fluorescent protein' named entity 'angiotensin' named entity 'membrane proteins' named entity 'canine coronavirus' named entity 'transmissible gastroenteritis virus' named entity 'genomes' named entity 'angiotensin' named entity 'SARS' named entity 'SARS-CoV' named entity 'mice' named entity 'cellular receptors' named entity 'fusion proteins' named entity 'tropisms' named entity 'shared feature' named entity 'coronaviruses' named entity 'pleiotropic' named entity 'viruses' named entity 'kidney' named entity 'lungs' named entity 'SARS-CoV' named entity 'type I transmembrane protein' named entity 'viral budding' named entity 'ACE2' named entity 'virus' named entity 'neutral pH' named entity 'neurotensin' named entity 'fusion proteins' named entity 'Coronavirus' named entity 'HCoV-229E' named entity 'SARS-CoV'

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