About: Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-β in Porcine Intestinal Epithelial Cells

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About: Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-β in Porcine Intestinal Epithelial Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-β in Porcine Intestinal Epithelial Cells
Creator	He, Qigai Liu, Pinghuang Li, Zili Qian, Shaoju Li, Shaowen Meng, Xianrong Li, Cui Cao, Rui Cui, Yijie Gao, Zitong Yang, Kang Jiang, Guochun Jones, Ian
Source	Medline; PMC
abstract	Transmissible gastroenteritis virus (TGEV) is a porcine intestinal coronavirus that causes fatal severe watery diarrhea in piglets. The neonatal Fc receptor (FcRn) is the only IgG transport receptor, its expression on mucosal surfaces is triggered upon viral stimulation, which significantly enhances mucosal immunity. We utilized TGEV as a model pathogen to explore the role of FcRn in resisting viral invasion in overall intestinal mucosal immunity. TGEV induced FcRn expression by activating NF-κB signaling in porcine small intestinal epithelial (IPEC-J2) cells, however, the underlying mechanisms are unclear. First, using small interfering RNAs, we found that TGEV up-regulated FcRn expression via TLR3, TLR9 and RIG-I. Moreover, TGEV induced IL-1β, IL-6, IL-8, TGF-β, and TNF-α production. TGF-β-stimulated IPEC-J2 cells highly up-regulated FcRn expression, while treatment with a JNK-specific inhibitor down-regulated the expression. TGEV nucleocapsid (N) protein also enhanced FcRn promoter activity via the NF-κB signaling pathway and its central region (aa 128–252) was essential for FcRn activation. Additionally, N protein-mediated FcRn up-regulation promotes IgG transcytosis. Thus, TGEV N protein and TGF-β up-regulated FcRn expression, further clarifying the molecular mechanism of up-regulation of FcRn expression by TGEV.
has issue date	2020-01-21(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.03085
bibo:pmid	32038538
has license	cc-by
sha1sum (hex)	be5a6b0a0bff9b130578c5ad71a6be32d16525d6
schema:url	https://doi.org/10.3389/fmicb.2019.03085
resource representing a document's title	Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-β in Porcine Intestinal Epithelial Cells
has PubMed Central identifier	PMC6990134
has PubMed identifier	32038538
schema:publication	Front Microbiol
resource representing a document's body	covid:be5a6b0a0bff9b130578c5ad71a6be32d16525d6#body_text
is schema:about of	named entity 'FCRN' named entity 'TLR3' named entity 'piglets' named entity 'up-regulated' named entity 'RNAs' named entity 'up-regulated' named entity 'Infection' named entity 'EXPRESSION' named entity 'TGF' named entity 'NUCLEOCAPSID' named entity 'INHIBITOR' named entity 'HIGHLY' named entity 'SECRETION' named entity 'UNDERLYING' named entity 'JNK' named entity 'SURFACES' named entity 'UNCLEAR' named entity 'CELLS' named entity 'INTESTINAL' named entity 'TGF' named entity 'PORCINE' named entity 'SMALL INTESTINAL' named entity 'SIGNALING' named entity 'STIMULATION' named entity 'FOUND' named entity 'TRANSPORT' named entity 'MUCOSAL' named entity 'DOWN-REGULATED' named entity 'PROTEIN ' named entity 'INDUCED' named entity 'SECTION' named entity 'PORCINE' named entity 'JOURNAL ' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'NUCLEOCAPSID PROTEIN' named entity 'EXPRESSION' named entity 'IGG' named entity 'INTESTINAL MUCOSAL IMMUNITY' named entity 'TLR3' named entity 'WATERY DIARRHEA' named entity 'CENTRAL REGION' named entity 'ESSENTIAL' named entity 'MICROBIOLOGY' named entity 'EPITHELIAL CELLS' named entity 'UP-REGULATES' named entity 'PROTEIN ' named entity 'TRIGGERED' named entity 'FATAL' named entity 'INVASION' named entity 'STIMULATED' named entity 'RECEPTOR' named entity 'MUCOSAL IMMUNITY' named entity 'MOLECULAR MECHANISM' named entity 'ACTIVATION' named entity 'EPITHELIAL' named entity 'FCRN' named entity 'PATHOGEN' named entity 'IL-8' named entity 'IL-1' named entity 'RESISTING' named entity 'TREATMENT' named entity 'VIRAL' named entity 'IL-6' named entity 'SEVERE' named entity 'USING' named entity 'MODEL' named entity 'TRANSCYTOSIS' named entity 'SMALL INTERFERING RNAS' named entity 'SIGNALING PATHWAY'

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