About: Alterations of the Gut Microbiota in Patients with COVID-19 or H1N1 Influenza

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About: Alterations of the Gut Microbiota in Patients with COVID-19 or H1N1 Influenza Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Alterations of the Gut Microbiota in Patients with COVID-19 or H1N1 Influenza
Creator	Zheng, Beiwen Luo, Rui Gao, Hainv Li, Lanjuan Huang, Chenjie Zhang, Hua Tang, Lingling Guo, Jing Lv, Longxian Zhang, Xuewu Chen, Yanfei Gu, Silan Zhang, Jiaying Chen, Yunbo Gong, Yiwen Guo, Feifei Jiang, Huiyong Lu, Haifeng Wu, Zhengjie Xu, Qiaomai Yan, Ren
Source	Medline; PMC
abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) is an emerging serious global health problem. Gastrointestinal symptoms are common in COVID-19 patients, and SARS-CoV-2 RNA has been detected in stool specimens. However, the relationship between the gut microbiome and disease remains to be established. METHODS: We conducted a cross-sectional study of 30 COVID-19 patients, 24 influenza A (H1N1) patients, and 30 matched healthy controls (HC) to identify differences in the gut microbiota by 16S ribosomal RNA (rRNA) gene V3-V4 region sequencing. RESULTS: Compared with HC, COVID-19 patients had significantly reduced bacterial diversity, a significantly higher relative abundance of opportunistic pathogens, such as Streptococcus, Rothia, Veillonella and Actinomyces, and a lower relative abundance of beneficial symbionts. Five biomarkers showed high accuracy for distinguishing COVID-19 patients from HC with an area under the curve (AUC) up to 0.89. Patients with H1N1 displayed lower diversity and different overall microbial composition compared with COVID-19 patients. Seven biomarkers were selected to distinguish the two cohorts with an AUC of 0.94. CONCLUSION: The gut microbial signature of patients with COVID-19 was different from that of H1N1 patients and HC. Our study suggests the potential value of the gut microbiota as a diagnostic biomarker and therapeutic target for COVID-19, but further validation is needed.
has issue date	2020-06-04(xsd:dateTime)
bibo:doi	10.1093/cid/ciaa709
bibo:pmid	32497191
has license	no-cc
sha1sum (hex)	be47a5668d6c9db9bbdc4daa2ae43862264a36f9
schema:url	https://doi.org/10.1093/cid/ciaa709
resource representing a document's title	Alterations of the Gut Microbiota in Patients with COVID-19 or H1N1 Influenza
has PubMed Central identifier	PMC7314193
has PubMed identifier	32497191
schema:publication	Clin Infect Dis
resource representing a document's body	covid:be47a5668d6c9db9bbdc4daa2ae43862264a36f9#body_text
is schema:about of	covid:arg/be47a5668d6c9db9bbdc4daa2ae43862264a36f9 named entity 'Rothia' named entity 'microbiota' named entity 'H1N1' named entity '16S ribosomal RNA' named entity 'Gastrointestinal symptoms' named entity 'Veillonella' named entity 'gut microbiota' named entity 'COVID' named entity 'H1N1' named entity 'Gut Microbiota' named entity 'COVID-19' named entity 'metabolism' named entity 'H1N1' named entity 'intestinal microflora' named entity 'COVID' named entity 'kidney' named entity 'seasonal influenza' named entity 'ACE2' named entity 'LDH' named entity 'H1N1' named entity 'inflammatory markers' named entity 'prognosis' named entity 'lung' named entity 'antiviral' named entity 'probiotics' named entity 'human health' named entity 'TNF-α' named entity '16S rRNA gene' named entity 'biomarkers' named entity 'correlation' named entity 'microbial' named entity 'influenza' named entity 'COVID' named entity 'C-reactive protein' named entity 'Ternary plot' named entity 'lymphocyte count' named entity 'ACE2' named entity 'H1N1' named entity 'ANOSIM' named entity 'OTUs' named entity 'SPSS' named entity 'COVID' named entity 'biomarkers' named entity 'COVID-19' named entity 'nutrient' named entity 'significant difference' named entity 'lung' named entity 'gut microbiome' named entity 'Shannon diversity index' named entity 'D-dimer' named entity 'COVID-19' named entity 'SPSS Inc.' named entity 'COVID-19' named entity 'physical examination' named entity 'body mass index' named entity 'COVID-19' named entity 'cross-sectional study' named entity 'IL-6' named entity 'lung' named entity 'biomarker'

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