About: Innate Resistance to Flavivirus Infections and the Functions of 2′-5′ Oligoadenylate Synthetases

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About: Innate Resistance to Flavivirus Infections and the Functions of 2′-5′ Oligoadenylate Synthetases Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Innate Resistance to Flavivirus Infections and the Functions of 2′-5′ Oligoadenylate Synthetases
Creator	Guénet, J.-L Mashimo, T Simon-Chazottes, D
source	Medline; PMC
abstract	Mouse susceptibility to experimental infections with flaviviruses is significantly influenced by a cluster of genes on chromosome 5 encoding a family of proteins with enzymatic properties, the 2′–5′ oligoadenylate synthetases (OAS). Positional cloning of the locus in question has revealed that susceptibility of laboratory inbred strains to this class of virus is associated with a nonsense mutation in the gene encoding the OAS1B isoform. Analysis of the molecular structure of the cluster in different mammalian species including human indicates that the cluster is extremely polymorphic with a highly variable number of genes and pseudogenes whose functions are not yet completely established. Although still preliminary, a few recent observations also substantiate a possible role for OAS1 in human susceptibility to viral infections (West Nile virus, SARS, etc.) and its possible involvement in some other diseases such as type 1 diabetes and multiple sclerosis. Finally, convergent observations indicate that the molecules encoded by the 2′–5′ OAS cluster might be involved in other fundamental cellular functions such as cell growth and differentiation, gene regulation, and apoptosis.
has issue date	2008-01-01(xsd:dateTime)
bibo:doi	10.1007/978-3-540-75203-5_4
bibo:pmid	18727488
has license	no-cc
sha1sum (hex)	be3c5419d94f3aa20abe46f4228fec784f770ebe
schema:url	https://doi.org/10.1007/978-3-540-75203-5_4
resource representing a document's title	Innate Resistance to Flavivirus Infections and the Functions of 2′-5′ Oligoadenylate Synthetases
has PubMed Central identifier	PMC7122621
has PubMed identifier	18727488
schema:publication	Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology
resource representing a document's body	covid:be3c5419d94f3aa20abe46f4228fec784f770ebe#body_text
is schema:about of	named entity 'involved' named entity 'Mouse' named entity 'observations' named entity 'functions' named entity 'susceptibility' named entity 'laboratory' named entity 'type 1 diabetes' named entity 'LABORATORY' named entity 'highly' named entity 'diseases' named entity 'isoform' named entity 'fundamental' named entity 'polymorphic' named entity 'cluster' named entity 'Positional cloning' named entity 'number' named entity 'West Nile virus' named entity 'cell growth' named entity 'Infections' named entity 'OAS' named entity 'pseudogenes' named entity 'Positional cloning' named entity 'isoform' named entity 'SARS' named entity 'molecular structure' named entity 'apoptosis' named entity 'virus' named entity 'genetic mapping' named entity 'virulence' named entity 'recessive trait' named entity 'enzyme' named entity 'virus' named entity 'OAS1' named entity 'environmental factors' named entity 'inbred strains' named entity 'flavivirus' named entity 'OAS3' named entity 'Oas1' named entity 'OAS1' named entity 'OAS1' named entity 'interferon' named entity 'phyla' named entity 'genetic basis' named entity 'pig' named entity 'molecular level' named entity 'OASL' named entity 'Flv' named entity 'SNPs' named entity 'virus' named entity 'mice' named entity 'Oas1' named entity 'OAS3' named entity 'environmental pressures' named entity 'RNase' named entity 'genetic basis' named entity 'hepatitis' named entity 'OAS1' named entity 'flavivirus' named entity 'OAS' named entity 'isoform' named entity 'mice' named entity 'gene' named entity 'stop codon' named entity 'STF' named entity 'genotype' named entity 'allele' named entity 'Sequence alignment' named entity 'fetal tissues' named entity 'mice' named entity 'single nucleotide polymorphisms' named entity 'enzyme' named entity 'IFN' named entity 'Oas1' named entity 'mice' named entity 'BALB' named entity 'inbred strain' named entity 'enzyme activity' named entity 'genetically engineered' named entity 'ovarian follicle'

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