About: DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients

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About: DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients
Creator	Haagmans, Bart Widagdo, W Bracke, Ken Brusselle, Guy Janssens, Wim Joos, Guy Kleinjan, Alex Leen, J Seys, Verhamme, Fien
Source	Medline; PMC
abstract	BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV) causes pneumonia with a relatively high case fatality rate in humans. Smokers and chronic obstructive pulmonary disease (COPD) patients have been reported to be more susceptible to MERS-CoV infection. Here, we determined the expression of MERS-CoV receptor, dipeptidyl peptidase IV (DPP4), in lung tissues of smokers without airflow limitation and COPD patients in comparison to nonsmoking individuals (never-smokers). METHODS: DPP4 expression was measured in lung tissue of lung resection specimens of never-smokers, smokers without airflow limitation, COPD GOLD stage II patients and in lung explants of end-stage COPD patients. Both control subjects and COPD patients were well phenotyped and age-matched. The mRNA expression was determined using qRT-PCR and protein expression was quantified using immunohistochemistry. RESULTS: In smokers and subjects with COPD, both DPP4 mRNA and protein expression were significantly higher compared to never-smokers. Additionally, we found that both DPP4 mRNA and protein expression were inversely correlated with lung function and diffusing capacity parameters. CONCLUSIONS: We provide evidence that DPP4 is upregulated in the lungs of smokers and COPD patients, which could partially explain why these individuals are more susceptible to MERS-CoV infection. These data also highlight a possible role of DPP4 in COPD pathogenesis.
has issue date	2018-01-01(xsd:dateTime)
bibo:doi	10.1093/cid/cix741
bibo:pmid	29020176
has license	no-cc
sha1sum (hex)	bdf62e9b24357ae780c54ec5a3f0849ccf9cdb07
schema:url	https://doi.org/10.1093/cid/cix741
resource representing a document's title	DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients
has PubMed Central identifier	PMC7108100
has PubMed identifier	29020176
schema:publication	Clin Infect Dis
resource representing a document's body	covid:bdf62e9b24357ae780c54ec5a3f0849ccf9cdb07#body_text
is schema:about of	named entity 'SMOKERS' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'UPREGULATED' named entity 'DPP4' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'CORONAVIRUS RECEPTOR' named entity 'HUMANS' named entity 'DETERMINED' named entity 'PNEUMONIA' named entity 'CASE FATALITY RATE' named entity 'BACKGROUND' named entity 'SMOKERS' named entity 'HIGH' named entity 'REPORTED' named entity 'RECEPTOR' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'COMPARISON' named entity 'COPD' named entity 'HERE' named entity 'INFECTION' named entity 'SUSCEPTIBLE' named entity 'DPP4' named entity 'LUNGS' named entity 'PATIENTS' named entity 'EXPRESSION' named entity 'PATIENTS' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'LUNG TISSUES' named entity 'INDIVIDUALS' named entity 'CAUSES' named entity 'DIPEPTIDYL PEPTIDASE IV' named entity 'HAVE' named entity 'AIRFLOW LIMITATION' covid:arg/bdf62e9b24357ae780c54ec5a3f0849ccf9cdb07 named entity 'airflow' named entity 'Chronic Obstructive Pulmonary Disease' named entity 'receptor' named entity 'MERS-CoV' named entity 'MERS-CoV' named entity 'DPP4' named entity 'Smokers' named entity 'COPD' named entity 'Smokers' named entity 'DPP4' named entity 'end-stage' named entity 'DPP4' named entity 'substrate' named entity 'DPP4' named entity 'epithelia' named entity 'Glostrup' named entity 'DPP4' named entity 'protein expression' named entity 'lung tissue' named entity 'upregulate' named entity 'DPP4' named entity 'smokers' named entity 'smokers' named entity 'smokers' named entity 'alveolar epithelial cells' named entity 'pulmonary infections' named entity 'pathogenesis' named entity 'lung transplantation' named entity 'DPP4' named entity 'bronchodilator' named entity 'COPD' named entity 'respiratory tract infection' named entity 'BSA' named entity 'chemokines' named entity 'Proximal' named entity 'FVC' named entity 'staining' named entity 'Ca2+'

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