About: Incidence of pulmonary embolism in non-critically ill COVID-19 patients. Predicting factors for a challenging diagnosis

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About: Incidence of pulmonary embolism in non-critically ill COVID-19 patients. Predicting factors for a challenging diagnosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Incidence of pulmonary embolism in non-critically ill COVID-19 patients. Predicting factors for a challenging diagnosis
Creator	Mestre-Gómez, B Obispo, · Abad-Motos, · Churruca-Sarasqueta, · Cortina-Camarero, · Franco-Moreno, · Lorente-Ramos, · Muñoz-Rivas, · Rogado, · Ruiz-Velasco, · Saez-Vaquero, · Salazar-Chiriboga, · Such-Diaz, · Torres-Macho, ·
Source	Medline; PMC
abstract	Recent studies suggest that thrombotic complications are a common phenomenon in the novel SARS-CoV-2 infection. The main objective of our study is to assess cumulative incidence of pulmonary embolism (PE) in non critically ill COVID-19 patients and to identify its predicting factors associated to the diagnosis of pulmonary embolism. We retrospectevely reviewed 452 electronic medical records of patients admitted to Internal Medicine Department of a secondary hospital in Madrid during Covid 19 pandemic outbreak. We included 91 patients who underwent a multidetector Computed Tomography pulmonary angiography(CTPA) during conventional hospitalization. The cumulative incidence of PE was assessed ant the clinical, analytical and radiological characteristics were compared between patients with and without PE. PE incidence was 6.4% (29/452 patients). Most patients with a confirmed diagnosed with PE recieved low molecular weight heparin (LMWH): 79.3% (23/29). D-dimer peak was significatly elevated in PE vs non PE patients (14,480 vs 7230 mcg/dL, p = 0.03). In multivariate analysis of patients who underwent a CTPA we found that plasma D-dimer peak was an independen predictor of PE with a best cut off point of > 5000 µg/dl (OR 3.77; IC95% (1.18–12.16), p = 0.03). We found ninefold increased risk of PE patients not suffering from dyslipidemia (OR 9.06; IC95% (1.88–43.60). Predictive value of AUC for ROC is 75.5%. We found a high incidence of PE in non critically ill hospitalized COVID 19 patients despite standard thromboprophylaxis. An increase in D-dimer levels is an independent predictor for PE, with a best cut-off point of > 5000 µg/ dl.
has issue date	2020-06-29(xsd:dateTime)
bibo:doi	10.1007/s11239-020-02190-9
bibo:pmid	32613385
has license	no-cc
sha1sum (hex)	bdeb5b445b9ddbcda4252523c72da034ccd5854d
schema:url	https://doi.org/10.1007/s11239-020-02190-9
resource representing a document's title	Incidence of pulmonary embolism in non-critically ill COVID-19 patients. Predicting factors for a challenging diagnosis
has PubMed Central identifier	PMC7327193
has PubMed identifier	32613385
schema:publication	J Thromb Thrombolysis
resource representing a document's body	covid:bdeb5b445b9ddbcda4252523c72da034ccd5854d#body_text
is schema:about of	named entity 'elevated' named entity 'D-dimer' named entity 'diagnosis' named entity 'Predicting' named entity 'embolism' named entity 'MADRID' named entity 'SECONDARY' named entity 'ELEVATED' named entity 'PREDICTING' named entity 'RISK OF' named entity 'HOSPITALIZATION' named entity 'CUMULATIVE INCIDENCE' named entity 'DIAGNOSED' named entity 'DIAGNOSIS' named entity 'CHARACTERISTICS' named entity 'Madrid' named entity 'hospitalization' named entity 'assessed' named entity 'embolism' named entity 'point' named entity 'patients' named entity 'radiological' named entity 'patients' named entity 'Covid' named entity 'critically ill' named entity 'Department' named entity 'incidence' named entity 'electronic medical records' named entity 'SARS-CoV-2' named entity 'cumulative incidence' named entity 'CTPA' named entity 'Covid 19 pandemic' named entity 'D-dimer' named entity 'low molecular weight heparin' named entity 'critically ill' named entity 'pulmonary embolism' named entity 'study population' named entity 'statistical analysis' named entity 'observational study' named entity 'inflammation' named entity 'respiratory symptoms' named entity 'thromboembolism' named entity 'normal distribution' named entity 'statistically significant' named entity 'pulmonary embolism' named entity 'critically ill' named entity 'thromboprophylaxis' named entity 'endothelial dysfunction' named entity 'Madrid' named entity 'risk factors' named entity 'ICU' named entity 'statistical difference' named entity 'critically ill' named entity 'CTPA' named entity 'lung' named entity 'risk factors' named entity 'body mass index' named entity 'prognosis' named entity 'COVID' named entity 'normal distribution' named entity 'VTE' named entity 'luminal' named entity 'nasopharyngeal' named entity 'venous thromboembolism' named entity 'DVT' named entity 'ferritin' named entity 'LMWH' named entity 'blood clot formation'

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