About: Differential exon expression in myelin basic protein transcripts during central nervous system (CNS) remyelination

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About: Differential exon expression in myelin basic protein transcripts during central nervous system (CNS) remyelination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Differential exon expression in myelin basic protein transcripts during central nervous system (CNS) remyelination
Creator	Dubois-Dalcq, Monique Holmes, Kathryn Friedrich, Victor Ferra, Francesca Jordan, Craig Weismiller, David
Source	PMC
abstract	1. In order to characterize some of the molecular events leading to repair of myelin in the adult central nervous system (CNS), we examined the expression of transcripts for myelin basic protein (MBP) during remyelination in the mouse. C57B1/6 mice develop a demyelinating disease when glial cells are selectively infected by the A59 strain of mouse coronavrius. The virus is spontaneously cleared from the mice by 4 weeks postinfection (WPI), a time when remyelination is starting. 2. At 3 WPI total MBP transcripts are decreased by 75% in demyelinating lesions compared to control white matter. Using RNase protection assays andin situ hybridization with probes for particular MBP exons, we detected an increase in MBP transcripts containing exon 2 information, coincident with the earliest histological signs of remyelination. 3. The expression of MBP transcripts containing exon 2 information was first seen clustered in the perinuclear cytoplasm of oligodendrocytes scattered within the lesions. This is reminiscent of the increased levels and perinuclear clustering of MBP transcripts containing exon 2 seen during early developmental myelination. The peak abundance of exon 2-containing transcripts in the lesions was 13-fold that seen in control white matter. At later stages of remyelination, additional forms of MBP transcripts (without exon 2) increased and their distribution was more diffuse. 4. Thus, during remyelination, preforms of MBP transcripts, which are normally present at low levels in the adult CNS, are abundantly expressed and regulated in a manner similar to that observed in developmental myelination.
has issue date	1990-01-01(xsd:dateTime)
bibo:doi	10.1007/bf00733631
bibo:pmid	1692262
has license	no-cc
sha1sum (hex)	bd54d9fb67935b02cbd73f4802c82aab63fbcce5
schema:url	https://doi.org/10.1007/bf00733631
resource representing a document's title	Differential exon expression in myelin basic protein transcripts during central nervous system (CNS) remyelination
has PubMed Central identifier	PMC7087849
has PubMed identifier	1692262
schema:publication	Cell Mol Neurobiol
resource representing a document's body	covid:bd54d9fb67935b02cbd73f4802c82aab63fbcce5#body_text
is schema:about of	named entity 'remyelination' named entity 'REPAIR' named entity 'myelin' named entity 'WPI' named entity 'cleared' named entity 'strain' named entity 'glial cells' named entity 'Messenger RNA' named entity 'hybridized' named entity 'CNS' named entity 'myelination' named entity 'exon' named entity 'lower than normal' named entity 'MBP' named entity 'mouse model' named entity 'plasmid' named entity 'CNS' named entity 'RNA' named entity 'mice' named entity 'Cryostat' named entity 'saltatory conduction' named entity 'exon' named entity 'spinal cord' named entity 'CNS' named entity 'MBP' named entity 'exon' named entity 'exon' named entity 'myelin' named entity 'spinal cords' named entity 'MBP' named entity 'mouse hepatitis virus' named entity 'spinal cord lesions' named entity 'remyelination' named entity 'lipids' named entity 'X-ray' named entity 'S. Young' named entity 'myelination' named entity 'interact' named entity 'exon' named entity 'Optical density' named entity 'hybridized' named entity 'staining' named entity 'osmium tetroxide' named entity 'nucleus' named entity 'MBP' named entity 'vacuolated' named entity 'demyelination' named entity 'MBP' named entity 'PBS' named entity 'antigen' named entity 'exon' named entity 'spinal cord' named entity 'GBq' named entity 'exon' named entity 'MBP' named entity 'demyelinated' named entity 'remyelination' named entity 'MBP' named entity 'oligodendrocytes' named entity 'messenger RNA' named entity 'A59' named entity 'remyelination' named entity 'highly conserved' named entity 'myelin' named entity 'glycerol' named entity 'single-stranded RNA' named entity 'ethanol' named entity 'exon' named entity 'myelin' named entity 'MBP' named entity 'myelin' named entity 'astrocyte' named entity 'infection' named entity 'MBP' named entity 'protein' named entity 'plasmid'

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