About: Abstract Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic hypermutation and class switch recombination. AID thus potentiates the humoral response to clear pathogens. Marking the 20th anniversary of the discovery of AID, we synthesize the current understanding of AID function. We discuss AID biochemistry and how error-free forms of DNA repair are co-opted to prioritize mutagenesis over accuracy during antibody diversification. We discuss the regulation of DNA double-strand break repair pathway during class switch recombination. We describe genomic targeting of AID as a multilayered process involving chromatin architecture, cis and trans-acting factors, and determining mutagenesis -- distinct from AID occupancy at loci that are spared from mutation.

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About: Abstract Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic hypermutation and class switch recombination. AID thus potentiates the humoral response to clear pathogens. Marking the 20th anniversary of the discovery of AID, we synthesize the current understanding of AID function. We discuss AID biochemistry and how error-free forms of DNA repair are co-opted to prioritize mutagenesis over accuracy during antibody diversification. We discuss the regulation of DNA double-strand break repair pathway during class switch recombination. We describe genomic targeting of AID as a multilayered process involving chromatin architecture, cis and trans-acting factors, and determining mutagenesis -- distinct from AID occupancy at loci that are spared from mutation. Goto Sponge NotDistinct Permalink

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type	abstract
value	Abstract Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes, leading to somatic hypermutation and class switch recombination. AID thus potentiates the humoral response to clear pathogens. Marking the 20th anniversary of the discovery of AID, we synthesize the current understanding of AID function. We discuss AID biochemistry and how error-free forms of DNA repair are co-opted to prioritize mutagenesis over accuracy during antibody diversification. We discuss the regulation of DNA double-strand break repair pathway during class switch recombination. We describe genomic targeting of AID as a multilayered process involving chromatin architecture, cis and trans-acting factors, and determining mutagenesis -- distinct from AID occupancy at loci that are spared from mutation.
part of	AID in Antibody Diversification: There and Back again
is abstract of	AID in Antibody Diversification: There and Back again
is hasSource of	covid:ann/target/94fe42fbe99002917d1571f96cfba810d9778c77 covid:ann/target/1fe20db6b9c99a8ec368756fdf2f7d52fa02b8a7 covid:ann/target/77dd9d34096f01c3f5e6d0f098716313e80199b5 covid:ann/target/40b9b09ef397d6031a5eb1fb0dcc2b33ad924a1d covid:ann/target/1387a81c34b3ec7d37687e2c9e7aba96e1b5e942 covid:ann/target/7b2f395e330aa1c029b82754f3bb1ebf07725be5 covid:ann/target/1d7b34577889d22d0648a1538c76739e5fa6eca6

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