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About:
Clinical Characteristics of Children with COVID-19: A Rapid Review and Meta-Analysis
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An Entity of Type :
schema:ScholarlyArticle
, within Data Space :
covidontheweb.inria.fr
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document(s)
Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Clinical Characteristics of Children with COVID-19: A Rapid Review and Meta-Analysis
Creator
Wang, Chenglin
Zhou, Qi
Li, Weiguo
Baskota, Muna
Lu, Shuya
Luo, Xufei
Ma, Yanfang
Shi, Qianling
Wang, Zijun
Xun, Yangqin
Zhai, Hui
Yang, Yinmei
Source
MedRxiv
abstract
Abstract Background: Most guidelines on COVID-19 published so far include recommendations for patients regardless of age. Clinicians need a more accurate understanding of the clinical characteristics of children with COVID-19. Methods: We searched studies reporting clinical characteristics in children with COVID-19 published until March 31, 2020. We screened the literature, extracted the data and evaluated the risk of bias and quality of evidence of the included studies. We combined some of the outcomes (symptoms) in a single-arm meta-analysis using a random-effects model. Results: Our search retrieved 49 studies, including 25 case reports, 23 case series and one cohort study, with a total of 1667 patients. Our meta-analysis showed that most children with COVID-19 have mild symptoms. Eighty-three percent of the children were within family clusters of cases, and 19% had no symptoms. At least 7% with digestive symptoms. The main symptoms of children were fever (48%, 95% confidence interval [CI]: 39%, 56%) and cough (39%, 95% CI: 30%, 48%). The lymphocyte count was below normal level in only 15% [95% CI: 8%, 22%] of children which is different from adult patients. 66% [95% CI: 55%, 77%] of children had abnormal findings in CT imaging. Conclusions: Most children with COVID-19 have only mild symptoms, and many children are asymptomatic. Fever and cough are the most common symptoms in children. Vomiting and diarrhea were not common in children. The lymphocyte count is usually within the normal range in children.
has issue date
2020-04-17
(
xsd:dateTime
)
bibo:doi
10.1101/2020.04.13.20064352
has license
medrxiv
sha1sum (hex)
bd028cdb7e70f740f9a1efe4b58255367814364b
schema:url
https://doi.org/10.1101/2020.04.13.20064352
resource representing a document's title
Clinical Characteristics of Children with COVID-19: A Rapid Review and Meta-Analysis
resource representing a document's body
covid:bd028cdb7e70f740f9a1efe4b58255367814364b#body_text
is
schema:about
of
named entity 'COVID-19'
named entity 'Characteristics'
named entity 'PUBLISHED'
named entity 'BACKGROUND'
named entity 'RECOMMENDATIONS'
named entity 'CHILDREN'
named entity 'age'
named entity 'Children'
named entity 'COVID-19'
named entity 'Clinical Characteristics'
named entity 'COVID-19'
named entity 'preprint'
named entity 'medRxiv'
named entity 'COVID-19'
named entity 'lymphocyte count'
named entity 'data collection'
named entity 'ground-glass opacities'
named entity 'copyright holder'
named entity 'COVID-19'
named entity 'lung'
named entity 'symptom'
named entity 'standard deviations'
named entity 'copyright holder'
named entity 'Chinese National Health Commission'
named entity 'preprint'
named entity 'medRxiv'
named entity 'normal range'
named entity 'medRxiv'
named entity 'case-control'
named entity 'pneumonia'
named entity 'preprint'
named entity 'clinical characteristics'
named entity 'copyright holder'
named entity 'CT image'
named entity 'meta-analysis'
named entity 'nucleic acid test'
named entity 'NICE'
named entity 'asymptomatic'
named entity 'antibody'
named entity 'incubation period'
named entity 'medRxiv'
named entity 'Epidemiologic'
named entity 'chest imaging'
named entity 'pneumonia'
named entity 'copyright holder'
named entity 'gastrointestinal'
named entity 'leucocyte count'
named entity 'copyright holder'
named entity 'normal range'
named entity 'gastrointestinal'
named entity 'peer-reviewed'
named entity 'inflammation'
named entity 'comorbidity'
named entity 'Clinical Presentation'
named entity 'medRxiv'
named entity 'public health'
named entity 'cohort studies'
named entity 'doi'
named entity 'medRxiv'
named entity 'medRxiv'
named entity 'lymphopenia'
named entity 'leucocyte count'
named entity 'statistically significant'
named entity 'lymphocyte count'
named entity 'preprint'
named entity 'COVID-19'
named entity 'COVID-19'
named entity 'preprint'
named entity 'COVID-19'
named entity 'diarrhea'
named entity 'preprint'
named entity 'copyright holder'
named entity 'preprint'
named entity 'hypertension'
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