About: Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto

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About: Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto
Creator	Wang, Lin-Fa Crameri, Gary Alonso, Sylvie Dutertre, Charles-Antoine Ginhoux, Florent Periasamy, Pravin Baker, Michelle Irving, Aaron Han, Justin Ng, Jia María Martínez Gómez, Julia
Source	Medline; PMC
abstract	The unique ability of bats to act as reservoir for viruses that are highly pathogenic to humans suggests unique properties and functional characteristics of their immune system. However, the lack of bat specific reagents, in particular antibodies, has limited our knowledge of bat’s immunity. Using cross-reactive antibodies, we report the phenotypic and functional characterization of T cell subsets, B and NK cells in the fruit-eating bat Pteropus alecto. Our findings indicate the predominance of CD8(+) T cells in the spleen from wild-caught bats that may reflect either the presence of viruses in this organ or predominance of this cell subset at steady state. Instead majority of T cells in circulation, lymph nodes and bone marrow (BM) were CD4(+) subsets. Interestingly, 40% of spleen T cells expressed constitutively IL-17, IL-22 and TGF-β mRNA, which may indicate a strong bias towards the Th17 and regulatory T cell subsets. Furthermore, the unexpected high number of T cells in bats BM could suggest an important role in T cell development. Finally, mitogenic stimulation induced proliferation and production of effector molecules by bats immune cells. This work contributes to a better understanding of bat’s immunity, opening up new perspectives of therapeutic interventions for humans.
has issue date	2016-11-24(xsd:dateTime)
bibo:doi	10.1038/srep37796
bibo:pmid	27883085
has license	cc-by
sha1sum (hex)	bca82a8723c167333ef1d73d5bf0fd900f30b695
schema:url	https://doi.org/10.1038/srep37796
resource representing a document's title	Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto
has PubMed Central identifier	PMC5121612
has PubMed identifier	27883085
schema:publication	Sci Rep
resource representing a document's body	covid:bca82a8723c167333ef1d73d5bf0fd900f30b695#body_text
is schema:about of	named entity 'OPEN' named entity 'BAT' named entity 'alecto' named entity 'opening' named entity 'bone marrow' named entity 'alecto' named entity 'MAJOR' named entity 'PATHOGENIC' named entity 'THEIR' named entity 'ANTIBODIES' named entity 'ROLE' named entity 'USING' named entity 'WILD-CAUGHT' named entity 'STRONG' named entity 'BONE MARROW' named entity 'FRUIT' named entity 'IMPORTANT' named entity 'SUGGEST' named entity 'WORK' named entity 'EFFECTOR' named entity 'IMMUNE SYSTEM' named entity 'CD8' named entity 'BATS' named entity 'ORGAN' named entity 'HUMANS' named entity 'RESERVOIR' named entity 'KNOWLEDGE' named entity 'TH17' named entity 'FINDINGS' named entity 'CELL' named entity 'NUMBER OF' named entity 'ACT' named entity 'PROLIFERATION' named entity 'PRODUCTION' named entity 'T CELL SUBSETS' named entity 'HIGH' named entity '40%' named entity 'ABILITY' named entity 'CHARACTERISTICS' named entity 'UNIQUE' named entity 'REPORT' named entity 'SPLEEN' named entity 'MITOGENIC' named entity 'THERAPEUTIC INTERVENTIONS' named entity 'REAGENTS' named entity 'STEADY STATE' named entity '27S' named entity 'TGF' named entity 'SPECIFIC' named entity 'HIGHLY' named entity 'INDUCED' named entity 'EXPRESSED' named entity 'UNDERSTANDING' named entity 'CHARACTERIZATION' named entity 'LACK' named entity 'OPENING' named entity 'PTEROPUS ALECTO' named entity 'POPULATIONS' named entity 'CHARACTERIZATION' named entity 'BAT' named entity 'REFLECT' covid:arg/bca82a8723c167333ef1d73d5bf0fd900f30b695 named entity 'IL-17' named entity 'EITHER' named entity 'PTEROPUS ALECTO' named entity 'FRUIT' named entity 'FUNCTIONAL' named entity 'PRESENCE OF' named entity 'VIRUSES' named entity 'MRNA' named entity 'CIRCULATION'

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