About: microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-induced Mitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 Receptor Accessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro

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About: microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-induced Mitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 Receptor Accessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-induced Mitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 Receptor Accessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro
Creator	Research; X, Z
source	Medline; PMC
abstract	Transmissible gastroenteritis virus (TGEV), a member of the coronaviridae family, could cause fatal diarrhea of piglets and result in numerous economic losses. Previous studies demonstrated that TGEV infection could lead to mitochondrial damage and upregulate miR-4331 level. So miR-4331 may play an important regulatory role in the control of mitochondrial function. To explore the potential role of miR-4331 in mitochondrial damage, we adopted a strategy consisting of quantitative proteomic analysis of porcine kidney (PK-15) cells in response to miR-4331 and TGEV infection. Eventually, 69 differentially expressed proteins were gained. The target of miR-4331 was identified. The effects of miR-4331 and its target RB1 on mitochondrial Ca(2+) level, mitochondrial membrane potential (MMP), interleukin-1 receptor accessory protein (IL1RAP), p38 MAPK signaling pathway were investigated. The results showed that miR-4331 elevated mitochondrial Ca(2+) level, reduced MMP, targets Retinoblastoma 1 (RB1), upregulated IL1RAP, and induced activation of p38 MAPK pathway during TGEV infection. RB1 was identified as the direct targets of miR-4331 and downregulated IL1RAP, suppressed the activation of p38 MPAK, and attenuated TGEV-induced mitochondrial damage. In addition, IL1RAP played a positive role in activating p38 MAPK signaling and negative role in TGEV-induced mitochondrial damage. The data indicate that miR-4331 aggravates TGEV-induced mitochondrial damage by repressing expression of RB1, promoting IL1RAP, and activating p38 MAPK pathway.
has issue date	2017-12-07(xsd:dateTime)
bibo:doi	10.1074/mcp.ra117.000432
bibo:pmid	29217619
has license	cc-by
sha1sum (hex)	bc91f45d3fb7fbedebffb850dbf2dc3d3c7c2142
schema:url	https://doi.org/10.1074/mcp.ra117.000432
resource representing a document's title	microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-induced Mitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 Receptor Accessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro
has PubMed Central identifier	PMC5795386
has PubMed identifier	29217619
schema:publication	Mol Cell Proteomics
resource representing a document's body	covid:bc91f45d3fb7fbedebffb850dbf2dc3d3c7c2142#body_text
is schema:about of	named entity 'elevated' named entity 'identified' named entity 'IL1RAP' named entity 'diarrhea' named entity 'RESPONSE TO' named entity 'UPREGULATED' named entity 'CORONAVIRIDAE' named entity 'QUANTITATIVE' named entity 'NUMEROUS' named entity 'LEAD' named entity 'RESULTS' named entity 'REDUCED' named entity 'LEVEL' named entity 'PROTEIN ' named entity 'PREVIOUS' named entity 'AGGRAVATES' named entity 'PORCINE' named entity 'CELLS' named entity 'ITS' named entity 'IDENTIFIED' named entity 'CAUSE' named entity 'DIRECT' named entity 'FATAL' named entity 'KIDNEY' named entity 'MIR' named entity 'POTENTIAL' named entity 'GAINED' named entity 'MMP' named entity 'MITOCHONDRIAL' named entity 'TARGETS' named entity 'ELEVATED' named entity 'PATHWAY' named entity 'P38 MAPK SIGNALING' named entity 'MITOCHONDRIAL MEMBRANE POTENTIAL' named entity 'CONTROL' named entity 'VETERINARY MEDICINE' named entity 'UNIVERSITY' named entity 'ATTENUATED' named entity 'EXPRESSION' named entity 'RETINOBLASTOMA 1' named entity 'PROTEOMIC ANALYSIS' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'DEMONSTRATED' named entity 'PLAY' named entity 'INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN' named entity 'STRATEGY' named entity 'RESULT' named entity 'SUPPRESSED' named entity 'IL1RAP' named entity 'ACTIVATION' named entity '80%' named entity 'AUTHOR CONTRIBUTIONS' named entity 'INVESTIGATED' named entity 'P38 MAPK SIGNALING PATHWAY' named entity 'ACTIVATION OF P38 MAPK' named entity 'ADOPTED' named entity 'POSITIVE' named entity 'ADDITION' named entity 'INDUCED' named entity 'RB1' named entity 'IMPORTANT' named entity 'TARGET' named entity 'REGULATORY ROLE' named entity 'DATA' named entity 'PROMOTING' named entity 'NEGATIVE' named entity 'ROLE' named entity 'ECONOMIC' named entity 'EFFECTS' named entity 'PROTEINS' named entity 'DIARRHEA' named entity 'NORTHWEST' named entity 'RESEARCH' named entity 'MITOCHONDRIAL DAMAGE' named entity 'INFECTION' named entity 'P38' named entity 'MITOCHONDRIAL FUNCTION' named entity 'STUDIES' named entity 'ACTIVATING' named entity 'MEMBER OF' named entity 'FAMILY'

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