About: Regioselective synthesis of plant (iso)flavone glycosides in Escherichia coli

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About: Regioselective synthesis of plant (iso)flavone glycosides in Escherichia coli Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regioselective synthesis of plant (iso)flavone glycosides in Escherichia coli
Creator	Dixon, Richard He, Xian-Zhi Li, Wen-Sheng Blount, W Jack, &
Source	PMC
abstract	The flavonoids genistein, biochanin A, luteolin, quercetin, and kaempferol are plant natural products with potentially useful pharmacological and nutraceutical activities. These natural products usually exist in plants as glycosides, and their glycosylation has a remarkable influence on their pharmacokinetic properties. The glycosyltransferases UGT71G1 and UGT73C8 from Medicago truncatula are excellent reagents for the regioselective glycosylation of (iso)flavonoids in Escherichia coli grown in Terrific broth. Ten to 20 mg/L of either genistein or biochanin A 7-O-glucoside was produced after feeding genistein or biochanin A to E. coli expressing UGT71G1, and similar levels of luteolin 4’-O- and 7-O-glucosides were produced after feeding luteolin to cultures expressing UGT73C8. For the production of kaempferol 3-O-glucoside or quercetin 3-O-glucoside, the Phe148Val or Tyr202Ala mutants of UGT71G1 were employed. Ten to 16 mg/L of either kaempferol 3-O- or quercetin 3-O-glucosides were produced on feeding kaempferol or quercetin to E. coli expressing these enzymes. More than 90% of the glucoside products were released to the medium, facilitating their isolation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00253-008-1554-7) contains supplementary material, which is available to authorized users.
has issue date	2008-08-01(xsd:dateTime)
bibo:doi	10.1007/s00253-008-1554-7
bibo:pmid	18568307
has license	no-cc
sha1sum (hex)	bc0e2ceac1f88a594c027cb2bb22d0c15015b83e
schema:url	https://doi.org/10.1007/s00253-008-1554-7
resource representing a document's title	Regioselective synthesis of plant (iso)flavone glycosides in Escherichia coli
has PubMed Central identifier	PMC2491422
has PubMed identifier	18568307
schema:publication	Appl Microbiol Biotechnol
resource representing a document's body	covid:bc0e2ceac1f88a594c027cb2bb22d0c15015b83e#body_text
is schema:about of	named entity 'alveolar' named entity 'facilitating' named entity 'melanoma' named entity 'flavonoids' named entity 'regioselective' named entity 'Flavonoids' named entity 'vesicles' named entity 'gene' named entity 'quercetin' named entity 'Brunetti' named entity 'Aiello' named entity 'QUERCETIN' named entity 'PROPERTIES' named entity 'QUERCETIN 3-O-GLUCOSIDE' named entity 'ENZYMES' named entity 'INFLAMMATION' named entity 'STEREOSELECTIVE SYNTHESIS' named entity 'MAJOR' named entity 'CALTAGIRONE' named entity 'BROTH' named entity 'EMPLOYED' named entity 'GLUCOSIDES' named entity 'MEDICAGO TRUNCATULA' named entity 'PHARMACOLOGICAL' named entity 'LUTEOLIN' named entity 'A 7' named entity 'SIMILAR' named entity 'employed' named entity 'Caltagirone' named entity 'feeding' named entity 'More' named entity 'released' named entity 'luteolin' named entity 'produced' named entity 'Ten' named entity 'feeding' named entity 'Natali' named entity 'Tetrahedron' named entity 'apigenin' named entity 'Terrific' named entity 'potential' named entity 'metastatic' named entity 'pharmacological' named entity 'jejunum' named entity 'gene expression' named entity 'genistein' named entity 'O-glucoside' named entity 'quercetin' named entity 'Luteolin' named entity 'glycosides' named entity 'Regioselective' named entity 'iso' named entity 'glucoside' named entity 'glycosylation' named entity 'Quercetin' named entity 'substrates' named entity 'quercetin' named entity 'nitrogen gas' named entity 'glycosylation' named entity 'culture medium' named entity 'epithelium' named entity 'flavone' named entity 'glycosyltransferases' named entity 'Insoluble' named entity 'glycosyltransferases' named entity 'protein purification' named entity 'O-glucosides' named entity 'luteolin' named entity 'substrate' named entity 'Willits' named entity 'flavonoids' named entity 'glucoside' named entity 'monoglucoside' named entity 'cardiovascular disease' named entity 'glycosides' named entity 'glycosides' named entity 'small molecule'

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