About: Genomic organization and expression of the 3′ end of the canine and feline enteric coronaviruses

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About: Genomic organization and expression of the 3′ end of the canine and feline enteric coronaviruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genomic organization and expression of the 3′ end of the canine and feline enteric coronaviruses
Creator	Horzinek, M Rossen, J Rot-Tier, P Vennema,', H Wesseling, J
Source	Elsevier; Medline; PMC
abstract	Abstract The genomic organization at the 3′ end of canine coronavirus (CCV) and feline enteric coronavirus (FECV) was determined by sequence analysis and compared to that of feline infectious peritonitis virus (FIPV) and transmissible gastroenteritis virus (TGEV) of swine. Comparison of the latter two has previously revealed an extra open reading frame (ORF) at the 3′ end of the FIPV genome, lacking in TGEV, which is currently designated ORF 6b. Both CCV and FECV possess 6b-related ORFs at the 3′ ends of their genomes. The presence of ORF 6b in three of four viruses in this antigenic cluster strongly suggests that TGEV has lost this ORF by deletion. The CCV ORF 6b is collinear with that of FIPV, but the predicted amino acid sequences are only 58% identical. The FECV ORF 6b contains a large deletion compared to that of FIPV, reducing the collinear part to 60%. The sequence homologies were highest between CCV and TGEV on the one hand and between FECV and FIPV on the other. Previously, we showed that the expression product of the FIPV ORF 6b can be detected in infected cells by immunoprecipitation (Vennema et al., 1992). In the present study we have performed similar experiments with CCV and FECV. In infected cells both viruses produced proteins related to but different from the FIPV 6b protein.
has issue date	1992-11-30(xsd:dateTime)
bibo:doi	10.1016/0042-6822(92)90174-n
bibo:pmid	1329312
has license	els-covid
sha1sum (hex)	bc0dec987603c780fd3d2fccc7b99478ccfdc38d
schema:url	https://doi.org/10.1016/0042-6822%2892%2990174-n
resource representing a document's title	Genomic organization and expression of the 3′ end of the canine and feline enteric coronaviruses
has PubMed Central identifier	PMC7131216
has PubMed identifier	1329312
schema:publication	Virology
resource representing a document's body	covid:bc0dec987603c780fd3d2fccc7b99478ccfdc38d#body_text
is schema:about of	named entity 'deletion' named entity 'ORF' named entity 'feline' named entity 'protein' named entity 'genome' named entity 'deletion' covid:arg/bc0dec987603c780fd3d2fccc7b99478ccfdc38d named entity 'infected' named entity 'sequence analysis' named entity 'The sequence' named entity 'expression' named entity 'proteins' named entity 'Comparison' named entity 'End' named entity 'transmissible gastroenteritis virus' named entity 'viruses' named entity 'coronavirus' named entity '3' end' named entity 'FIPV' named entity 'TGEV' named entity 'canine coronavirus' named entity 'FIPV' named entity 'antigenic' named entity 'TGEV' named entity 'feline infectious peritonitis virus' named entity 'TGEV' named entity 'digestion' named entity 'Stratagene' named entity 'vaccinia virus' named entity 'viral proteins' named entity 'nucleotides' named entity 'vaccinia virus' named entity 'ascites fluid' named entity 'mRNA' named entity 'PCR amplification' named entity 'feline coronavirus' named entity 'gene' named entity 'amino acid sequences' named entity 'oligonucleotide' named entity 'PCR amplification' named entity 'antigenicity' named entity 'mannose' named entity 'open reading frame' named entity 'primers' named entity 'Oligonucleotide' named entity 'T7 DNA polymerase' named entity 'expression vector' named entity 'TGEV' named entity 'tissue culture' named entity 'genome' named entity 'N-glycosylation site' named entity 'PCR amplification' named entity 'TGEV' named entity 'hydrophobic' named entity 'FIPV' named entity 'TGEV' named entity 'carboxyl-terminus' named entity 'SDS-PAGE' named entity 'PCR amplification' named entity 'homologies' named entity 'antigenic' named entity 'sequenced' named entity 'laboratory strain' named entity 'Biochemicals' named entity 'cross-reactive' named entity 'structural proteins' named entity 'FIPV' named entity 'kbp' named entity 'FIPV' named entity 'TGEV' named entity 'primers' named entity 'sequence analysis' named entity 'nucleotide' named entity 'Sequence analysis' named entity 'cDNA' named entity 'FIPV' named entity 'recombinant'

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