About: Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation

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About: Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation
Creator	Buck Louis, Germaine Kannan, Kurunthachalam Mendola, Pauline Ouidir, Marion Tekola-Ayele, Fasil Zhang, Cuilin
source	PMC
abstract	BACKGROUND: Prenatal maternal plasma persistent organic pollutant (POP) concentrations have been associated with neonatal outcomes. However, the underlying mechanisms remain unknown. Placental epigenetic mechanisms may be involved, but no prior epigenome-wide studies have investigated the impact of maternal POPs on placental DNA methylation. We studied the association between maternal plasma POP concentration in early pregnancy and epigenome-wide placental DNA methylation among 260 pregnant women from the NICHD Fetal Growth Studies. RESULTS: Our analysis focused on POPs with more than 80% plasma concentrations above the limit of quantification, including 3 organochlorine pesticides (hexachlorobenzene, trans-nonachlor, p,p’-dichlorodiphenyldichloroethylene), 1 polybrominated diphenyl ether (PBDE 47), 3 polychlorinated biphenyls (138/158, 153, 180), and 6 poly- and perfluorinated alkyl substances (PFASs) (perfluorodecanoic acid, perfluorohexanesulfonic acid, perfluorononanoic acid, perfluorooctanesulfonic acid, perfluoroundecanoic acid (PFUnDA)). Using 5% false discovery rate, POPs were associated with a total of 214 differentially methylated CpG sites (nominal p values ranging from 2.61 × 10(−21) to 2.11 × 10(−7)). Out of the 214 CpG sites, 24 (11%) were significantly correlated with placental expression of 21 genes. Notably, higher PFUnDA was associated with increased methylation at 3 CpG sites (cg13996963, cg12089439, cg18145877) annotated to TUSC3, and increased methylation at those 3 CpG sites was correlated with decreased expression of TUSC3 in the placenta. Increased methylation at cg18145877 (TUSC3) and decreased expression of TUSC3 were correlated with shorter birth length. Out of the 214 CpG sites, methylation at 44 CpG sites was correlated (p value < 0.10) with at least one neonatal anthropometry measure (i.e., birth weight, birth length, and head circumference). Seven CpG sites mediated (p value < 0.05) the association between PBDE 47 and neonatal anthropometry measures. Genes annotating the top differentially methylated CpG sites were enriched in pathways related to differentiation of embryonic cells (PBDE 47) and in pathways related to brain size and brain morphology (PFASs). CONCLUSIONS: DNA methylation changes in the placenta were significantly associated with maternal plasma POPs concentration. The findings suggest that placental DNA methylation and gene expression mechanism may be involved in the prenatal toxicity of POPs and their association with neonatal anthropometry measures.
has issue date	2020-07-13(xsd:dateTime)
bibo:doi	10.1186/s13148-020-00894-6
has license	cc-by
sha1sum (hex)	bbcbaa07d3d599c2836df9771eab8058f8f0a30c
schema:url	https://doi.org/10.1186/s13148-020-00894-6
resource representing a document's title	Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation
has PubMed Central identifier	PMC7371466
schema:publication	Clin Epigenetics
resource representing a document's body	covid:bbcbaa07d3d599c2836df9771eab8058f8f0a30c#body_text
is schema:about of	named entity 'NICHD' named entity 'BUT' named entity 'Prenatal' named entity 'epigenome' named entity 'plasma' named entity 'early pregnancy' named entity 'persistent organic pollutants' named entity 'DNA methylation' named entity 'PBDE' named entity 'plasma' named entity 'placental' named entity 'birth weight' named entity 'DNA methylation' named entity 'correlation' named entity '0.01' named entity 'CpG' named entity 'health outcomes' named entity 'base pairs' named entity 'body weight' named entity 'methylation' named entity 'CpG' named entity 'Akaike information criterion' named entity 'RNA-seq' named entity 'plasma' named entity 'methylation' named entity 'TUSC3' named entity 'persistent organic pollutants' named entity 'placenta' named entity 'cord blood' named entity '0.49' named entity 'FDR' named entity 'plasma' named entity 'polybrominated diphenyl ether' named entity 'tissue biopsies' named entity 'strength of association' named entity 'CpG sites' named entity 'total cholesterol' named entity 'DMR' named entity 'PBDE' named entity 'placental' named entity 'anthropometry' named entity 'birth weight' named entity 'Canonical Pathway' named entity 'gene expression' named entity 'schizophrenia' named entity 'PBDE' named entity 'gene expression' named entity 'birth weight' named entity 'BMI' named entity 'pregnant women' named entity 'CpG sites' named entity 'DMR' named entity 'CpG' named entity 'methylation' named entity 'placental' named entity 'CpG sites' named entity 'CpG sites' named entity 'anthropometry' named entity 'white blood cells' named entity 'PFNA' named entity 'CpG sites' named entity 'birth weight' named entity 'mediation analysis' named entity 'FDR' named entity 'false discovery rate' named entity 'embryonic cells' named entity 'neonatal' named entity 'neurodevelopmental disorders' named entity 'limit of quantification' named entity 'PBDE' named entity 'standard deviations' named entity 'CpG' named entity 'DNA methylation' named entity 'statistical test' named entity 'hexachlorobenzene' named entity 'FDR' named entity 'plasma' named entity 'SELK'

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