About: Low Doses of Ochratoxin-A Decrease IgY and IgA Production in Broiler Chicks

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Low Doses of Ochratoxin-A Decrease IgY and IgA Production in Broiler Chicks
Creator	Oba, Alexandre Fernandes, Flaiban, Karina Hirooka, Id, Eduardo Id, Elisa Itano, Eiko Khan, Shahzad Venancio, Emerson
Source	PMC
abstract	The mycotoxin, ochratoxin-A (OTA), produced by some fungi, and is a natural contaminant of many foods and animal feeds worldwide. Due to its toxic effects, the recommended maximum daily intake of OTA for poultry feeds is 0.1 mg OTA/kg (ECR2006/575/EC); this dose does not induce changes in hepatic/renal parameters, but decreases thymus size and serum globulin concentrations. Accordingly, in this study, we assessed quantitatively the total circulating IgY and IgA serum levels, in chicks consuming a 0.1 mg OTA/kg diet (limit) and higher doses (0.3–1.1 mg OTA/kg diet) for 14 or 21 days. We also evaluated other immunological parameters (thymus, bursa of Fabricius, and spleen weights and leukocyte profiles) at day 21. Decreased IgY serum levels were observed in all OTA-treated groups (p < 0.05). In the low-dose group, IgA levels were decreased on day 21, but not on day 14. The size of the thymus and the bursa of Fabricius was decreased in all OTA-treated groups (p < 0.05), whereas reduced spleen size and altered leukocyte profiles were detected only in the high-dose group (p < 0.05). We concluded that chronic exposure to OTA, even at the recommended highest dose, affected IgY and IgA production in chicks.
has issue date	2018-08-06(xsd:dateTime)
bibo:doi	10.3390/toxins10080316
bibo:pmid	30082604
has license	cc-by
sha1sum (hex)	bbcba5769c3aef1594790aa0d845ba112a0e1ab1
schema:url	https://doi.org/10.3390/toxins10080316
resource representing a document's title	Low Doses of Ochratoxin-A Decrease IgY and IgA Production in Broiler Chicks
has PubMed Central identifier	PMC6115841
has PubMed identifier	30082604
schema:publication	Toxins (Basel)
resource representing a document's body	covid:bbcba5769c3aef1594790aa0d845ba112a0e1ab1#body_text
is schema:about of	named entity 'dose' named entity 'feeds' named entity 'chronic' named entity 'day' named entity 'CIRCULATING' named entity 'CONSUMING' named entity 'ALTERED' covid:arg/bbcba5769c3aef1594790aa0d845ba112a0e1ab1 named entity 'HIGHEST' named entity 'IMMUNOLOGICAL' named entity 'MAXIMUM' named entity 'HEPATIC' named entity 'PARAMETERS' named entity 'HIGH-DOSE' named entity 'DECREASE' named entity 'OCHRATOXIN' named entity 'CHICKS' named entity 'WORLDWIDE' named entity '0.05' named entity 'CHICKS' named entity 'STUDY' named entity 'BUT' named entity 'TOTAL' named entity 'DOES NOT' named entity 'GROUP' named entity 'SPLEEN' named entity '0.1' named entity 'AFFECTED' named entity 'OBSERVED' named entity 'TREATED' named entity 'DOSE' named entity 'INDUCE' named entity 'TOXIC EFFECTS' named entity 'EVALUATED' named entity 'IGY' named entity 'PRODUCTION' named entity 'IGA' named entity 'DIET' named entity 'CHRONIC EXPOSURE' named entity '1.1' named entity 'MYCOTOXIN' named entity 'DOSES' named entity 'LOW' named entity 'LEUKOCYTE' named entity 'FUNGI' named entity 'ASSESSED' named entity 'GROUPS' named entity 'SERUM' named entity 'DETECTED' named entity 'CONTAMINANT' named entity 'PRODUCTION' named entity 'EXPOSURE TO' named entity 'CONCENTRATIONS' named entity 'DAILY INTAKE' named entity 'SIZE' named entity '28P' named entity 'DECREASES' named entity 'LEVELS' named entity 'DECREASED' named entity 'POULTRY' named entity 'ANIMAL FEEDS' named entity 'CHANGES' named entity 'REDUCED SPLEEN SIZE' named entity 'FOODS' named entity 'IGA LEVELS' named entity 'OCHRATOXIN' named entity 'ITS' named entity 'THYMUS' named entity 'HIGHER' named entity 'BURSA OF FABRICIUS' named entity 'IS A' named entity 'FEEDS' named entity 'NATURAL'

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