About: Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China

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About: Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China
Creator	Xu, Lin Liu, Yi Chen, Yan-Mei Hu, Yi Pei, Yuan-Yuan Song, Zhi-Gang Tao, Zhao-Wu Tian, Jun-Hua Wang, Qi-Min Wang, Wen Wu, Fan Yu, Bin Yuan, Ming-Li Zhang, Yu-Ling Zhao, Su Zheng, Jiao-Jiao Holmes, Edward Dai, Hu, Zhi-Gang Song,
source	BioRxiv; MedRxiv
abstract	Emerging and re-emerging infectious diseases, such as SARS, MERS, Zika and highly pathogenic influenza present a major threat to public health1–3. Despite intense research effort, how, when and where novel diseases appear are still the source of considerable uncertainly. A severe respiratory disease was recently reported in the city of Wuhan, Hubei province, China. At the time of writing, at least 62 suspected cases have been reported since the first patient was hospitalized on December 12nd 2019. Epidemiological investigation by the local Center for Disease Control and Prevention (CDC) suggested that the outbreak was associated with a sea food market in Wuhan. We studied seven patients who were workers at the market, and collected bronchoalveolar lavage fluid (BALF) from one patient who exhibited a severe respiratory syndrome including fever, dizziness and cough, and who was admitted to Wuhan Central Hospital on December 26th 2019. Next generation metagenomic RNA sequencing4 identified a novel RNA virus from the family Coronaviridae designed WH-Human-1 coronavirus (WHCV). Phylogenetic analysis of the complete viral genome (29,903 nucleotides) revealed that WHCV was most closely related (89.1% nucleotide similarity similarity) to a group of Severe Acute Respiratory Syndrome (SARS)-like coronaviruses (genus Betacoronavirus, subgenus Sarbecovirus) previously sampled from bats in China and that have a history of genomic recombination. This outbreak highlights the ongoing capacity of viral spill-over from animals to cause severe disease in humans.
has issue date	2020-01-25(xsd:dateTime)
bibo:doi	10.1101/2020.01.24.919183
has license	biorxiv
sha1sum (hex)	bb97f90ff5bfd41f2f1148c5cbdb257fdba535df
schema:url	https://doi.org/10.1101/2020.01.24.919183
resource representing a document's title	Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China
schema:publication	bioRxiv
resource representing a document's body	covid:bb97f90ff5bfd41f2f1148c5cbdb257fdba535df#body_text
is schema:about of	named entity 'RNA' named entity 'revealed' named entity 'patient' named entity 'ranging' named entity 'cough' named entity 'capacity' named entity 'flow' named entity 'observed' named entity 'Table' named entity 'investigation' named entity 'respiratory disease' covid:arg/bb97f90ff5bfd41f2f1148c5cbdb257fdba535df named entity '2019' named entity 'severe' named entity 'patient' named entity 'nucleotide' named entity 'city' named entity 'antibiotic' named entity 'suspected' named entity 'respiratory failure' named entity 'severe' named entity 'Patients' named entity 'time' named entity 'suggested' named entity 'Patients' named entity 'body temperatures' named entity 'patients' named entity 'Coronaviridae' named entity 'bronchoalveolar lavage fluid' named entity 'disease' named entity 'influenza' named entity 'cough' named entity 'phlegm' named entity 'Hubei province' named entity 'respiratory disease' named entity 'fever' named entity 'RNA virus' named entity 'dyspnea' named entity 'preprint' named entity '3, 4' named entity 'sea food market' named entity 'fever' named entity 'Severe Acute Respiratory Syndrome' named entity 'Streptococcus' named entity 'antibiotic' named entity 'glucocorticoid' named entity 'Wuhan' named entity 'patients' named entity 'SARS' named entity 'bioRxiv' named entity 'contigs' named entity 'preprint' named entity 'protein structure' named entity 'SARS-like coronavirus' named entity 'bioRxiv' named entity 'bioRxiv' named entity 'virus genome' named entity 'PCR' named entity 'Betacoronavirus' named entity 'genome sequence' named entity 'genome' named entity 'nucleotide sequences' named entity 'RNA-seq' named entity 'HKU1' named entity 'bioRxiv'

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