About: Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease
Creator	Ghezzi, Pietro Tirouvanziam, Rabindra De, S Staal, Frank Andrus, J Andrus, James Atkuri, Kondala Bottiglieri, Teodoro Cotgreave, Ian De Rosa, Stephen Ela, Stephen Fred, Rosa Frye, Richard Ghezzi, P Herzenberg, Leonard Herzenberg, Leonore Heydari, Kartoosh Holmgren, A Holmgren, Arne Jahoor, Farook Jones, D Jones, Dean Kaplowitz, Neil Kopke, Richard Lemley, K Lemley, Kevin Mantovani, John Nakamura, Hajime Sahaf, Bita Sahaf, · Zolopa, Andrew
Source	PMC
abstract	Glutathione (GSH) deficiency may play a pivotal role in a variety of apparently unrelated clinical conditions and diseases. Orally administered N-acetylcysteine (NAC), which replenishes the cysteine required for GSH synthesis, has been tested in a large number of randomized placebo-controlled trials involving these diseases and conditions. This chapter focused on developing a base of evidence suggesting that NAC administration improves disease by increasing cysteine and/or GSH in a variety of diseases, thereby implying a significant role for GSH deficiency in the clinical basis of many diseases. To develop this base of evidence, we systematically selected studies which considered the hypothesis that the therapeutic efficacy for NAC is an indication that cysteine and/or GSH deficiency is a pathophysiological part of the diseases studied. In this manner we focus this chapter on explaining the biological mechanisms of NAC therapy in a wide variety of disorders and demonstrate its ubiquitous role in improving disease that involves disrupted GSH and/or cysteine metabolism. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/978-981-10-5311-5_20) contains supplementary material, which is available to authorized users.
has issue date	2018-07-19(xsd:dateTime)
bibo:doi	10.1007/978-981-10-5311-5_20
has license	no-cc
sha1sum (hex)	bb72c2d66c8a951d11f8b6f327ef9fa8952bab3d
schema:url	https://doi.org/10.1007/978-981-10-5311-5_20
resource representing a document's title	Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease
has PubMed Central identifier	PMC7120747
schema:publication	The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine
resource representing a document's body	covid:bb72c2d66c8a951d11f8b6f327ef9fa8952bab3d#body_text
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