About: A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model

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About: A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model
Creator	Drosten, Christian Osterrieder, Nikolaus Hippenstiel, Stefan Hocke, Andreas Suttorp, Norbert Dietert, Kristina Witzenrath, Martin Höltje, Markus Lee, Chang-Chun Müller, Marcel Corman, Victor Gruber, Achim Schmidt, Marie Wilson, Ian Wu, Nicholas Sander, Leif Yuan, Meng Bertzbach, Luca Zhu, Xueyong Abdelgawad, Azza Barthel, Paula Endres, Matthias Franke, Christiana Hoffmann, Julius Homeyer, Marie Jeworowski, Lara Kornau, Hans-Christian Kreye, Jakob Kurth, Florian Li, Lucie Liu, Hejun Prüss, Harald Reincke, S Richter, Anja Schmitz, Dietmar Schwarz, Tatjana Skriner, Karl Stöffler, Laura Sánchez-Sendin, Elisa Trimpert, Jakob Van Hoof, Scott Vladimirova, Daria Von Wardenburg, Niels Wendisch, Daniel
Source	BioRxiv; Medline; PMC
abstract	The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019 (COVID-19), manifesting with respiratory symptoms and multi-organ dysfunction. Detailed characterization of virus-neutralizing antibodies and target epitopes is needed to understand COVID-19 pathophysiology and guide immunization strategies. Among 598 human monoclonal antibodies (mAbs) from ten COVID-19 patients, we identified 40 strongly neutralizing mAbs. The most potent mAb CV07-209 neutralized authentic SARS-CoV-2 with IC50 of 3.1 ng/ml. Crystal structures of two mAbs in complex with the SARS-CoV-2 receptor-binding domain at 2.55 and 2.70 Å revealed a direct block of ACE2 attachment. Interestingly, some of the near-germline SARS-CoV-2 neutralizing mAbs reacted with mammalian self-antigens. Prophylactic and therapeutic application of CV07-209 protected hamsters from SARS-CoV-2 infection, weight loss and lung pathology. Our results show that non-self-reactive virus-neutralizing mAbs elicited during SARS-CoV-2 infection are a promising therapeutic strategy.
has issue date	2020-08-16(xsd:dateTime)
bibo:doi	10.1101/2020.08.15.252320
bibo:pmid	32817952
has license	biorxiv
sha1sum (hex)	bb60fd19ac05ac835b542601832238c4418aa21e
schema:url	https://doi.org/10.1101/2020.08.15.252320
resource representing a document's title	A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model
has PubMed Central identifier	PMC7430590
has PubMed identifier	32817952
schema:publication	bioRxiv
resource representing a document's body	covid:bb60fd19ac05ac835b542601832238c4418aa21e#body_text
is schema:about of	named entity 'revealed' named entity 'ACE2' named entity 'neutralizing' named entity 'mAbs' named entity 'hamster' named entity 'authentic' named entity 'SARS-CoV-2' named entity 'led' named entity 'therapeutic' named entity 'domain' named entity 'monoclonal antibodies' named entity 'SARS-CoV-2' named entity 'attachment' named entity 'neutralized' named entity 'COVID-19' named entity 'infection' named entity 'antibodies' named entity 'immunization' named entity 'germline' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'emergence' named entity 'antibody' named entity 'murine' named entity 'SARS-CoV-2' named entity 'respiratory symptoms' named entity 'X-ray crystallography' named entity 'clinical remission' named entity 'mAb' named entity 'weight loss' named entity 'IC50' named entity 'germline' named entity 'affinity maturation' named entity 'PCR' named entity 'COVID-19' named entity 'bronchial epithelial cells' named entity 'ACE2'

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