About: Aeromonas salmonicida Infection Only Moderately Regulates Expression of Factors Contributing to Toll-Like Receptor Signaling but Massively Activates the Cellular and Humoral Branches of Innate Immunity in Rainbow Trout (Oncorhynchus mykiss)

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About: Aeromonas salmonicida Infection Only Moderately Regulates Expression of Factors Contributing to Toll-Like Receptor Signaling but Massively Activates the Cellular and Humoral Branches of Innate Immunity in Rainbow Trout (Oncorhynchus mykiss) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Aeromonas salmonicida Infection Only Moderately Regulates Expression of Factors Contributing to Toll-Like Receptor Signaling but Massively Activates the Cellular and Humoral Branches of Innate Immunity in Rainbow Trout (Oncorhynchus mykiss)
Creator	Brietzke, Andreas Goldammer, Tom Jaros, Joanna Köllner, Bernd Rebl, Alexander Seyfert, Hans-Martin Korytál, Tomáš
Source	PMC
abstract	Toll-like receptors (TLRs) are known to detect a defined spectrum of microbial structures. However, the knowledge about the specificity of teleost Tlr factors for distinct pathogens is limited so far. We measured baseline expression profiles of 18 tlr genes and associated signaling factors in four immune-relevant tissues of rainbow trout Oncorhynchus mykiss. Intraperitoneal injection of a lethal dose of Aeromonas salmonicida subsp. salmonicida induced highly increased levels of cytokine mRNAs during a 72-hour postinfection (hpi) period. In contrast, only the fish-specific tlr22a2 and the downstream factor irak1 featured clearly increased transcript levels, while the mRNA concentrations of many other tlr genes decreased. Flow cytometry quantified cell trafficking after infection indicating a dramatic influx of myeloid cells into the peritoneum and a belated low level immigration of lymphoid cells. T and B lymphocytes were differentiated with RT-qPCR revealing that B lymphocytes emigrated from and T lymphocytes immigrated into head kidney. In conclusion, no specific TLR can be singled out as a dominant receptor for A. salmonicida. The recruitment of cellular factors of innate immunity rather than induced expression of pathogen receptors is hence of key importance for mounting a first immune defense against invading A. salmonicida.
has issue date	2015-07-22(xsd:dateTime)
bibo:doi	10.1155/2015/901015
bibo:pmid	26266270
has license	cc-by
sha1sum (hex)	bae5b0168a883973407af7229c5f3b59020cdfa4
schema:url	https://doi.org/10.1155/2015/901015
resource representing a document's title	Aeromonas salmonicida Infection Only Moderately Regulates Expression of Factors Contributing to Toll-Like Receptor Signaling but Massively Activates the Cellular and Humoral Branches of Innate Immunity in Rainbow Trout (Oncorhynchus mykiss)
has PubMed Central identifier	PMC4525466
has PubMed identifier	26266270
schema:publication	J Immunol Res
resource representing a document's body	covid:bae5b0168a883973407af7229c5f3b59020cdfa4#body_text
is schema:about of	named entity 'featured' named entity 'levels' named entity 'dominant' named entity 'pathogens' named entity 'contrast' named entity 'hpi' named entity 'factors' named entity 'lethal dose' named entity 'MODERATELY' named entity 'STRUCTURES' named entity 'INTRAPERITONEAL INJECTION' named entity 'TRAFFICKING' named entity 'LOW LEVEL' named entity 'CONCLUSION' named entity 'INCREASED' named entity 'LIMITED' named entity 'RECEPTORS' named entity 'HOUR' named entity 'FACTOR' named entity 'ASSOCIATED' named entity 'DOWNSTREAM' named entity 'B LYMPHOCYTES' covid:arg/bae5b0168a883973407af7229c5f3b59020cdfa4 named entity 'PATHOGENS' named entity 'FISH' named entity 'TISSUES' named entity 'CONCENTRATIONS' named entity 'PERIOD' named entity 'ACTIVATES' named entity 'TOLL-LIKE RECEPTOR SIGNALING' named entity 'CONTRIBUTING' named entity 'INFECTION ONLY' named entity 'SPECTRUM' named entity 'FLOW CYTOMETRY' named entity 'MEASURED' named entity 'ONCORHYNCHUS MYKISS' named entity 'DIFFERENTIATED' named entity 'CELL' named entity 'BRANCHES' named entity 'INNATE IMMUNITY' named entity 'CELLULAR' named entity 'AEROMONAS SALMONICIDA' named entity 'BUT' named entity 'TOLL-LIKE RECEPTORS' named entity 'IRAK1' named entity 'LETHAL DOSE' named entity 'CONTRAST' named entity 'KNOWN' named entity 'TO DETECT' named entity 'RECRUITMENT' named entity 'EXPRESSION' named entity 'KEY' named entity 'MICROBIAL' named entity 'LEVELS' named entity 'TELEOST' named entity 'IMMUNE' named entity 'INDICATING' named entity 'A 72' named entity 'RT-QPCR' named entity 'MOUNTING' named entity 'DEFINED' named entity 'INDUCED' named entity 'CELLULAR' named entity 'SPECIFIC' named entity 'LYMPHOID CELLS' named entity 'SIGNALING' named entity 'MRNA' named entity 'SPECIFICITY' named entity 'FAR' named entity 'HEAD KIDNEY' named entity 'GENES' named entity 'HIGHLY' named entity 'RELEVANT' named entity 'MYELOID CELLS' named entity 'INFECTION'

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