About: Cancer is associated with coronavirus disease (COVID-19) severity and mortality: A pooled analysis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cancer is associated with coronavirus disease (COVID-19) severity and mortality: A pooled analysis
Creator	Cheruiyot, Isaac Kipkorir, Vincent Misiani, Musa Munguti, Jeremiah Ngure, Brian
Source	Elsevier; PMC
abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) is a rapidly escalating pandemic that has spread to many parts of the world. As such, there is urgent need to identify predictors of clinical severity in COVID-19 patients. This may be useful for early identification of patients who may require life-saving interventions. In this meta-analysis, we evaluated whether malignancies are associated with a significantly enhanced odds of COVID-19 severity and mortality. METHOD: A systematic search of literature was conducted between November 1, 2019, to May 26th, 2020 on PubMed and China National Knowledge Infrastructure (CNKI) to identify studies reporting data on cancers in patients with or without severe COVID-19 were included. The primary outcome of interest was the association between malignancies and COVID-19 severity, while the secondary outcome was the association between malignancies and COVID-19 mortality. Data were pooled into a meta-analysis to estimate pooled odds ratio (OR) with 95% confidence interval (95% CI) for either outcome. RESULTS: A total of 20 studies (n = 4549 patients) were included. Overall, malignancies were found to be associated with significantly increased odds of COVID-19 severity (OR = 2.17; 95% CI 1.47–3.196; p < 0.001) and mortality (OR = 2.39; 95% CI 1.18–4.85; p = 0.016). No heterogeneity was observed for both outcomes (Cochran's Q = 6.558, p = 0.922, I(2) = 0% and Cochran's Q = 2.91, p = 0.71, I(2) = 0% respectively). CONCLUSION: Malignancies were significantly associated with a 2-fold increase in the odds of developing severe COVID-19 disease, as well as mortality. Larger studies are needed to corroborate these findings. These patients should be closely monitored for any signs of unfavorable disease progression.
has issue date	2020-08-20(xsd:dateTime)
bibo:doi	10.1016/j.ajem.2020.08.025
has license	no-cc
sha1sum (hex)	bae06199b661c29d7e42d84e18efb2e28ade059a
schema:url	https://doi.org/10.1016/j.ajem.2020.08.025
resource representing a document's title	Cancer is associated with coronavirus disease (COVID-19) severity and mortality: A pooled analysis
has PubMed Central identifier	PMC7438273
schema:publication	Am J Emerg Med
resource representing a document's body	covid:bae06199b661c29d7e42d84e18efb2e28ade059a#body_text
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